A NEW FAMILY OF 5-CARBON IMINOALDITOLS WHICH ARE POTENT GLYCOSIDASE INHIBITORS

被引：79
|
作者：
BERNOTAS, RC [1 ]
PAPANDREOU, G [1 ]
URBACH, J [1 ]
GANEM, B [1 ]
机构：
[1] CORNELL UNIV,DEPT CHEM,BAKER LAB,ITHACA,NY 14853
来源：
TETRAHEDRON LETTERS | 1990年 / 31卷 / 24期
关键词：
D O I：
10.1016/S0040-4039(00)97405-7
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of 1,5-dideoxy-1,5-imino-D-xylitol 2 (and the enantiomeric iminoalditols 3 and 4) is described. Alditol 2 compares favorably with 1-deoxynojirimycin 1 as a potent inhibitor of β-glucosidase. © 1990.
引用
收藏
页码：3393 / 3396
页数：4
相关论文
共 50 条
  • [31] Synthesis of C2 alkynylated purines, a new family of potent inhibitors of cyclin-dependent kinases
    Legraverend, M
    Ludwig, O
    Bisagni, E
    Leclerc, S
    Meijer, L
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1998, 8 (07) : 793 - 798
  • [32] Preparation and biological activity of manno- and galacto-validamines, new 5a-carba-glycosylamines as alpha-glycosidase inhibitors
    Kameda, Y
    Kawashima, K
    Takeuchi, M
    Ikeda, K
    Asano, N
    Matsui, K
    CARBOHYDRATE RESEARCH, 1997, 300 (03) : 259 - 264
  • [33] DEVELOPMENT OF L-689,065 - THE PROTOTYPE OF A NEW CLASS OF POTENT 5-LIPOXYGENASE INHIBITORS
    HUTCHINSON, JH
    PRASIT, P
    CHOO, LY
    RIENDEAU, D
    CHARLESON, S
    EVANS, JF
    PIECHUTA, H
    BALL, RG
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1992, 2 (12) : 1699 - 1702
  • [34] N-alkyl-3-decarboxy-3-hydroxymethylsiastatin B, a new family of glycosidase inhibitors of gem-diamine 1-N-iminosugars
    Kondo, KI
    Adachi, H
    Nishimura, Y
    Takeuchi, T
    NATURAL PRODUCT LETTERS, 2001, 15 (06): : 371 - 375
  • [35] Flexible synthesis and biological activity of uronic acid-type gem-diamine 1-N-iminosugars:: A new family of glycosidase inhibitors
    Nishimura, Y
    Shitara, E
    Adachi, H
    Toyoshima, M
    Nakajima, M
    Okami, Y
    Takeuchi, T
    JOURNAL OF ORGANIC CHEMISTRY, 2000, 65 (01): : 2 - 11
  • [36] 3-amino-1,2-benzisoxazoles: A new family of potent inhibitors of LTB(4) binding to the human neutrophils
    Suh, H
    Jeong, SJ
    Han, YN
    Lee, HJ
    Ryu, JH
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (04) : 389 - 392
  • [37] A new family of densely functionalized fused-benzoquinones as potent human protein kinase CK2 inhibitors
    Martin-Acosta, Pedro
    Haider, Samer
    Amesty, Angel
    Aichele, Dagmar
    Jose, Joachim
    Estevez-Braun, Ana
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 144 : 410 - 423
  • [38] A new family of potent TLR9 agonists, EnanDIM, which inhibit tumor growth in various syngeneic murine models
    Volz, B.
    Kapp, K.
    Oswald, D.
    Wittig, B.
    Schmidt, M.
    EUROPEAN JOURNAL OF CANCER, 2018, 92 : S5 - S6
  • [39] Synthesis and biological evaluation of potent glycosidase inhibitors: N-phenyl cyclic isourea derivatives of 5-amino- and 5-amino-C-(hydroxymethyl)-1,2,3,4-cyclopentanetetraols
    Uchida, C
    Kimura, H
    Ogawa, S
    BIOORGANIC & MEDICINAL CHEMISTRY, 1997, 5 (05) : 921 - 939
  • [40] NEW POTENT INHIBITORS OF 3 BETA-HYDROXY-DELTA-5-STEROID OXIDOREDUCTASE WITH SHORT DURATION OF ACTION
    BEGUE, RJ
    GUSTAFSSON, JA
    GOLDMAN, AS
    ENDOCRINOLOGY, 1974, 95 (01) : 238 - 246
12345