AZICEMICIN-A AND AZICEMICIN-B, A NEW ANTIMICROBIAL AGENT PRODUCED BY AMYCOLATOPSIS .1. TAXONOMY, FERMENTATION, ISOLATION, CHARACTERIZATION AND BIOLOGICAL-ACTIVITIES

被引：39
|
作者：
TSUCHIDA, T
IINUMA, H
KINOSHITA, N
IKEDA, T
SAWA, T
HAMADA, M
TAKEUCHI, T
机构：
[1] Institute of Microbial Chemistry, Shinagawa-ku Tokyo 141
来源：
JOURNAL OF ANTIBIOTICS | 1995年 / 48卷 / 03期
关键词：
D O I：
10.7164/antibiotics.48.217
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
A new structural class of the antibiotic, azicemicins A (1) and B (2) were isolated from the culture broth of the strain MJ126-NF4, which was closely related to Amycolatopsis sulphurea. They were purified by adsorption on Diaion HP-20, silica gel column chromatography and preparative TLC. The molecular formulas of 1 and 2 were determined to be C23H25O9N and C22H23O9N by HRFAB-MS, respectively. Azicemicins A and B have moderate growth inhibiting activity against Gram-positive bacteria and mycobacteria.
引用
收藏
页码：217 / 221
页数：5
相关论文
共 50 条
  • [41] OKILACTOMYCIN, A NOVEL ANTIBIOTIC PRODUCED BY A STREPTOMYCES SPECIES .1. TAXONOMY, FERMENTATION, ISOLATION AND CHARACTERIZATION
    IMAI, H
    SUZUKI, KI
    MORIOKA, M
    NUMASAKI, Y
    KADOTA, S
    NAGAI, K
    SATO, T
    IWANAMI, M
    SAITO, T
    JOURNAL OF ANTIBIOTICS, 1987, 40 (11): : 1475 - 1482
  • [42] THRAZARINE, A NEW ANTITUMOR ANTIBIOTIC .1. TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL PROPERTIES
    KAMEYAMA, T
    TAKAHASHI, A
    MATSUMOTO, H
    KURASAWA, S
    HAMADA, M
    OKAMI, Y
    ISHIZUKA, M
    TAKEUCHI, T
    JOURNAL OF ANTIBIOTICS, 1988, 41 (11): : 1561 - 1567
  • [43] WS-7338, NEW ENDOTHELIN RECEPTOR ANTAGONISTS ISOLATED FROM STREPTOMYCES SP NO 7338 .1. TAXONOMY, FERMENTATION, ISOLATION, PHYSICOCHEMICAL PROPERTIES AND BIOLOGICAL-ACTIVITIES
    MIYATA, S
    HASHIMOTO, M
    MASUI, Y
    EZAKI, M
    TAKASE, S
    NISHIKAWA, M
    KIYOTO, S
    OKUHARA, M
    KOHSAKA, M
    JOURNAL OF ANTIBIOTICS, 1992, 45 (01): : 74 - 82
  • [44] A NEW TOPOISOMERASE-II INHIBITOR, BE-10988, PRODUCED BY A STREPTOMYCETE .1. TAXONOMY, FERMENTATION, ISOLATION AND CHARACTERIZATION
    OKA, H
    YOSHINARI, T
    MURAI, T
    KAWAMURA, K
    SATOH, F
    FUNAISHI, K
    OKURA, A
    SUDA, H
    OKANISHI, M
    SHIZURI, Y
    JOURNAL OF ANTIBIOTICS, 1991, 44 (05): : 486 - 491
  • [45] Piperastatin A, a new selective serine carboxypeptidase inhibitor produced by actinomycete .1. Taxonomy, production, isolation and biological activities
    Murakami, S
    Harada, S
    Yamazaki, T
    Takahashi, Y
    Hamada, M
    Takeuchi, T
    Aoyagi, T
    JOURNAL OF ENZYME INHIBITION, 1996, 10 (02): : 93 - 103
  • [46] CHRYMUTASINS - NOVEL-AGLYCONE ANTITUMOR ANTIBIOTICS FROM A MUTANT OF STREPTOMYCES-CHARTREUSIS .1. TAXONOMY, MUTATION, FERMENTATION, ISOLATION AND BIOLOGICAL-ACTIVITIES
    UCHIDA, H
    NAKAKITA, Y
    ENOKI, N
    ABE, N
    NAKAMURA, T
    MUNEKATA, M
    JOURNAL OF ANTIBIOTICS, 1994, 47 (06): : 648 - 654
  • [47] LACHNUMON AND LACHNUMOL-A, NEW METABOLITES WITH NEMATOCIDAL AND ANTIMICROBIAL ACTIVITIES FROM THE ASCOMYCETE LACHNUM-PAPYRACEUM (KARST) KARST .1. PRODUCING ORGANISM, FERMENTATION, ISOLATION AND BIOLOGICAL-ACTIVITIES
    STADLER, M
    ANKE, H
    ARENDHOLZ, WR
    HANSSKE, F
    ANDERS, U
    STERNER, O
    BERGQUIST, KE
    JOURNAL OF ANTIBIOTICS, 1993, 46 (06): : 961 - 967
  • [48] SPOREAMICIN-A, A NEW MACROLIDE ANTIBIOTIC .1. TAXONOMY, FERMENTATION, ISOLATION AND CHARACTERIZATION
    YAGINUMA, S
    MORISHITA, A
    ISHIZAWA, K
    MUROFUSHI, S
    HAYASHI, M
    MUTOH, N
    JOURNAL OF ANTIBIOTICS, 1992, 45 (05): : 599 - 606
  • [49] EPOCARBAZOLIN-A AND EPOCARBAZOLIN-B, NOVEL 5-LIPOXYGENASE INHIBITORS - TAXONOMY, FERMENTATION, ISOLATION, STRUCTURES AND BIOLOGICAL-ACTIVITIES
    NIHEI, Y
    YAMAMOTO, H
    HASEGAWA, M
    HANADA, M
    FUKAGAWA, Y
    OKI, T
    JOURNAL OF ANTIBIOTICS, 1993, 46 (01): : 25 - 33
  • [50] RS-22A, RS-22B AND RS-22C - NEW MACROLIDE ANTIBIOTICS FROM STREPTOMYCES-VIOLACEUSNIGER .1. TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL-ACTIVITIES
    UBUKATA, M
    SHIRAISHI, N
    KOBINATA, K
    KUDO, T
    YAMAGUCHI, I
    OSADA, H
    SHEN, YC
    ISONO, K
    JOURNAL OF ANTIBIOTICS, 1995, 48 (04): : 289 - 292
12345