ANTIBODY-RESPONSE TO INACTIVATED INFLUENZA VACCINES OF VARIOUS ANTIGENIC CONCENTRATIONS

被引：22
|
作者：
SULLIVAN, KM [1 ]
MONTO, AS [1 ]
FOSTER, DA [1 ]
机构：
[1] UNIV MICHIGAN,DEPT EPIDEMIOL,ANN ARBOR,MI 48109
来源：
JOURNAL OF INFECTIOUS DISEASES | 1990年 / 161卷 / 02期
关键词：
D O I：
10.1093/infdis/161.2.333
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Four inactivated influenza vaccines (containing the recommended antigens for the 1985-1986 influenza season) of various antigenic concentration levels were randomly administered to 140 study participants. The effect of the increasing antigen concentration resulted in significantly higher influenza hemagglutination inhibition (HI) antibody levels 3 weeks after vaccination for the A/H1N1 antigen but not for the A/H3N2 or B antigens. Also, at 3 weeks after vaccination, there were significantly lower antibody titer levels associated with increasing age for the A/H1N1 and B antigens (adjusting for the prevaccination antibody titer and antigen content). © 1990 by The University of Chicago. All rights reserved.
引用
收藏
页码：333 / 335
页数：3
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