THE SWI SNF COMPLEX - A CHROMATIN REMODELING MACHINE

被引：346
|
作者：
PETERSON, CL
TAMKUN, JW
机构：
[1] UNIV MASSACHUSETTS,MED CTR,DEPT BIOCHEM & MOLEC BIOL,WORCESTER,MA 01605
[2] UNIV CALIF SANTA CRUZ,DEPT BIOL,SANTA CRUZ,CA 95064
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1995年 / 20卷 / 04期
关键词：
D O I：
10.1016/S0968-0004(00)88990-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The SWI-SNF complex plays a key role in the regulation of eukaryotic gene expression. Genetic studies in the yeast Saccharomyces cerevisiae suggest that one role for the complex is to antagonize chromatin-mediated repression of transcription. Recent biochemical studies indicate that S. cerevisiae and putative human SWI-SNF complexes use the energy of ATP hydrolysis to disrupt nucleosome structure.
引用
收藏
页码：143 / 146
页数：4
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