Comparison of hemodynamic stability and recovery profile with sevoflurane as inhalational agent versus propofol as total intravenous anesthesia during laparoscopic surgeries

Background and Aim: Propofol and sevoflurane, both meet the criteria of rapid smooth induction, hemodynamic stability, rapid recovery with minimal side effects. The present study investigated the hemodynamic stability and recovery profile while maintaining anesthesia with sevoflurane as inhalational agent versus propofol as total intravenous anesthesia during laparoscopic surgeries. Methodology: This was a prospective study conducted for one year at our hospital. Using convenient sampling technique, a total of 50 adult patients of American Society of Anesthesiologists (ASA) physical status I or II, aged between 18-60 years, of either sex, who were scheduled for elective day care surgeries of less than 2-hour duration under general anesthesia were selected for the study after informed consent. All the patients were randomly allocated into one of the two groups using computer generated random number table. Group-S received induction with propofol and maintenance with sevoflurane, while Group-P was induced and maintained with propofol only. Hemodynamic and recovery profiles were then compared. The differences between two groups were analyzed using unpaired t-test while categorical variables were analyzed using chi-square test. All the statistical tests were performed in Epi Info 3.5.1 software by CDC, USA. (6)p < 0.05was considered as statistically significant while p < 0.01 was considered as statistically highly significant. Results: The baseline demographic analysis showed that the two groups did not differ significantly in age, weight, sex, ASA grade and operative times. During the course of surgery, heart rate was significantly low in Group-P at 45 to 60 min than in Group-S. Systolic and diastolic blood pressures were significantly low during maintenance of anesthesia with propofol as compared to sevoflurane. Group-S showed significantly shorter time for spontaneous eye opening and recalling names and recognizing surroundings. Post-operative nausea and vomiting was significantly low in Group-P. Conclusion: The present study concludes that patients in both groups were hemodynamically stable. Sevoflurane has the added advantage of providing rapid emergence and recovery of cognitive function. Hence it can be considered as a useful alternative to propofol for maintenance of anesthesia.