DTBB-CATALYZED LITHIATION OF 1,4-DICHLORO-2-BUTYNE UNDER BARBIER CONDITIONS - SYNTHESIS OF FUNCTIONALIZED ALKYNES

被引：20
|
作者：
GUIJARRO, A [1 ]
YUS, M [1 ]
机构：
[1] UNIV ALICANTE,FAC CIENCIAS,DEPT QUIM ORGAN,E-03080 ALACANT,SPAIN
来源：
TETRAHEDRON | 1995年 / 51卷 / 01期
关键词：
D O I：
10.1016/0040-4020(94)00936-O
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The reaction of 1,2-dichloro-2-butyne (1) with an excess of lithium powder and a catalytic amount of 4,4'-di-tert-butylbiphenyl (DTBB, 2.5 mol %) in the presence of an electrophile [Me(3)SiCl, Bu(t)CHO, Me(2)CO, Et(2)CO, (CH2)(4)CO, (CH2)(5)CO, (CH2)(7)CO] in THF at -40 degrees C leads, after hydrolysis with water, to the corresponding disubstituted acetylenes 2 in moderate yields.
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页码：231 / 234
页数：4
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