EFFECT OF DL ALPHA-LIPOIC ACID ON TISSUE LIPID-PEROXIDATION AND ANTIOXIDANT SYSTEMS IN NORMAL AND GLYCOLATE TREATED RATS

被引：42
|
作者：
SUMATHI, R [1 ]
JAYANTHI, S [1 ]
KALPANADEVI, V [1 ]
VARALAKSHMI, P [1 ]
机构：
[1] UNIV MADRAS,DR AL MUDALIAR POSTGRAD INST BASIC MED SCI,DEPT MED BIOCHEM,MADRAS 600113,INDIA
来源：
PHARMACOLOGICAL RESEARCH | 1993年 / 27卷 / 04期
关键词：
GLYCOLATE; LIPOIC ACID; LIVER; KIDNEY; LIPID PEROXIDATION;
D O I：
10.1006/phrs.1993.1031
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The cytoprotective activity of α-lipoic acid against free radical toxicity, manifested during experimental hyperoxaluria, has been investigated. Glycollate was used as the inducer of oxalate hyperoxaluria in rats. The increase in lipid peroxidation and superoxide dismutase (SOD) activity, associated with a decrease in catalase activity and glutathione (GSH) level, are the salient features observed in tissues of hyperoxaluric rats. Free radical toxicity in the glycollate fed rats is effectively counteracted by lipoic acid administration. Lipoic acid administration brought about a significant decrease in peroxidative levels with an increase in catalase activity and glutathione level. These observations highlight the antioxidant property of α-lipoic acid and its cytoprotective action against experimental hyperoxaluria. © 1993 Academic Press. All rights reserved.
引用
收藏
页码：309 / 318
页数：10
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