A RAPID METHOD FOR EVALUATION OF ANALGESIC AND ANTIINFLAMMATORY ACTIVITY IN RATS

被引：0
|
作者：
RAO, CS
MURALIDHAR, N
NAIDU, MUR
JUNNARKAR, AY
SINGH, PP
机构：
来源：
INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY | 1991年 / 29卷 / 02期
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中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Carrageenin (2%) was used to produce edema and hyperalgesia; indomethacin, phenylbutazone, aspirin, ibuprofen, analgin, paracetamol and phenacetin were tested at different doses for anti-inflammatory and analgesic activity in the same rats as the peak for the edema reached at the end of 3rd hr and for the hyperalgesia at the end of 4th hr. Indomethacin, phenylbutazone and ibuprofen reduced edema and increased the pain threshold. Analgin and aspirin increased the pain threshold relatively at a low dose. Paracetamol and phenacetin were inactive in the doses tested. Carrageenin (2%) was observed to possess both phlogistic and algogenic properties.
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页码：120 / 122
页数：3
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