OPTIMIZATION OF A CULTURE-MEDIUM FOR STREPTOMYCIN PRODUCTION USING RESPONSE-SURFACE METHODOLOGY

被引：24

作者：

SAVAL, S ^{[1
]}

PABLOS, L ^{[1
]}

SANCHEZ, S ^{[1
]}

机构：

[1] NATL AUTONOMOUS UNIV MEXICO,FAC VET MED & ZOOTECH,DEPT GENET & STAT,MEXICO CITY,DF,MEXICO

来源：

BIORESOURCE TECHNOLOGY | 1993年 / 43卷 / 01期

关键词：

STREPTOMYCIN; OPTIMIZATION OF CULTURE MEDIUM; RESPONSE-SURFACE METHODOLOGY; EXPERIMENTAL DESIGN;

D O I：

10.1016/0960-8524(93)90077-O

中图分类号：

S2 [农业工程];

学科分类号：

0828 ;

摘要：

The effects of all ingredients of a culture medium designed for streptomycin production were evaluated in order to select the variables which influenced antibiotic production. Among them, glucose, beer-yeast autolyzate, sodium chloride and dibasic potassium phosphate showed a substantial effect on this parameter and were therefore selected. The optimum concentration for each variable was determined using an orthogonal-central composite experimental design and the response-surface methodology. The determination coefficient (R2) of the fitted second-order model was 0.9384. Applying this model, the optimum concentration of the four variables was obtained and with this optimized medium the streptomycin titre was increased by 52% with respect to the original medium, using an industrial strain of Streptomyces griseus.

引用

页码：19 / 25

页数：7

共 50 条

[1] Optimization of Fermentation Culture Medium for Sanghuangporus alpinus Using Response-Surface Methodology
Gao, Yuhan
Li, Xiaomin
Xu, Hui
Sun, Huijuan
Zhang, Junli
Wu, Xiaoping
Fu, Junsheng
[J]. HORTICULTURAE, 2024, 10 (05)
[2] OPTIMIZATION OF ACETONE-BUTANOL PRODUCTION USING RESPONSE-SURFACE METHODOLOGY
BADR, HR
HAMDY, MK
[J]. BIOMASS & BIOENERGY, 1992, 3 (01): : 49 - 55
[3] Optimization of Culture Medium for Polysaccharides Production of Antrodia camphorate using Response Surface Methodology
Zhou, Yu
Sheng, Fan Qing
Juan, Chen
Jiang Xinghua
Lu, Wang Jiang
Rong, Shen Qi
Heng, Fu Jin
[J]. JOURNAL OF PURE AND APPLIED MICROBIOLOGY, 2014, 8 (06): : 4309 - 4316
[4] OPTIMIZATION IN SIMULATION EXPERIMENTS USING RESPONSE-SURFACE METHODOLOGY
SAFIZADEH, MH
THORNTON, BM
[J]. COMPUTERS & INDUSTRIAL ENGINEERING, 1984, 8 (01) : 11 - 27
[5] RESPONSE-SURFACE METHODOLOGY AND PRODUCT OPTIMIZATION
GIOVANNI, M
[J]. FOOD TECHNOLOGY, 1983, 37 (11) : 41 - &
[6] OPTIMIZATION OF CARROT DEHYDRATION PROCESS USING RESPONSE-SURFACE METHODOLOGY
MUDAHAR, GS
TOLEDO, RT
FLOROS, JD
JEN, JJ
[J]. JOURNAL OF FOOD SCIENCE, 1989, 54 (03) : 714 - 719
[7] Optimization of lipids' ultrasonic extraction and production from Chlorella sp using response-surface methodology
Hadrich, Bilel
Akremi, Ismahen
Dammak, Mouna
Barkallah, Mohamed
Fendri, Imen
Abdelkafi, Slim
[J]. LIPIDS IN HEALTH AND DISEASE, 2018, 17
[8] Optimization of culture medium for yellow pigments production with Monascus anka mutant using response surface methodology
Bo Zhou
Jufang Wang
Yuewu Pu
Mingjun Zhu
Shiming Liu
Shizhong Liang
[J]. European Food Research and Technology, 2009, 228 : 895 - 901
[9] Optimization of culture medium for yellow pigments production with Monascus anka mutant using response surface methodology
Zhou, Bo
Wang, Jufang
Pu, Yuewu
Zhu, Mingjun
Liu, Shiming
Liang, Shizhong
[J]. EUROPEAN FOOD RESEARCH AND TECHNOLOGY, 2009, 228 (06) : 895 - 901
[10] Optimization of a culture medium for ligninolytic enzyme production and synthetic dye decolorization using response surface methodology
Trupkin, S
Levin, L
Forchiassin, F
Viale, A
[J]. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, 2003, 30 (12) : 682 - 690

← 1 2 3 4 5 →