Productivity Loss of Rheumatoid Arthritis Patients according to the Their Stages of the Disease Activity Score

被引：2

作者：

Bae, Sang-Cheol ^{[1
]}

Cha, Jin-Hye ^{[2
]}

Choe, Jung-Yoon ^{[3
]}

Choi, Sung Jae ^{[4
]}

Cho, Soo-Kyung ^{[1
]}

Chung, Won-Tae ^{[5
]}

Joung, Chung-Il ^{[6
]}

Jung, Young-Ok ^{[7
]}

Kang, Young Mo ^{[8
]}

Kim, Dong-Wook ^{[9
]}

Kim, Jinseok ^{[10
]}

Kim, Young-Joo ^{[2
]}

Lee, Choong-Ki ^{[11
]}

Lee, Hye-Soon ^{[12
]}

Lee, Jisoo ^{[13
]}

Lee, Sang-Heon ^{[14
]}

Lee, Sang-Hoon ^{[15
]}

Lee, Shin-Seok ^{[16
]}

Lee, Yeon-Ah ^{[17
]}

Nah, Seong-Su ^{[18
]}

Shim, Seung Cheol ^{[19
]}

Song, Gwan-Gyu ^{[20
]}

Suh, Chang-Hee ^{[21
]}

Won, Soyoung ^{[1
]}

Yoo, Wan-Hee ^{[22
]}

Yoon, Bo Young ^{[23
]}

机构：

[1] Hanyang Univ Hosp Rheumat Dis, Dept Rheumatol, 222 Wangsimni Ro, Seoul 04763, South Korea

[2] Pfizer Pharmaceut Korea Ltd, Corp Affairs & Hlth & Value Div, Outcomes Res Real World Data Team, Seoul, South Korea

[3] Catholic Univ Daegu, Sch Med, Dept Internal Med, Div Rheumatol, Daegu, South Korea

[4] Korea Univ, Ansan Hosp, Div Rheumatol, Ansan, South Korea

[5] Dong A Univ Hosp, Dept Rheumatol, Busan, South Korea

[6] Konyang Univ Hosp, Dept Rheumatol, Daejeon, South Korea

[7] Hallym Univ, Kangnam Sacred Heart Hosp, Dept Rheumatol, Seoul, South Korea

[8] Kyungpook Natl Univ Hosp, Dept Rheumatol, Daegu, South Korea

[9] Inje Univ Busan, Paik Hosp, Dept Rheumatol, Busan, South Korea

[10] Jeju Natl Univ, Sch Med, Dept Rheumatol, Jeju, South Korea

[11] Yeongnam Univ Hosp, Dept Infect Dis & Rheumatol, Daegu, South Korea

[12] Hangyang Univ, Guri Hosp, Dept Rheumatol, Guri, South Korea

[13] Ewha Womans Univ, Mokdong Hosp, Div Rheumatol, Seoul, South Korea

[14] Konkuk Univ, Med Ctr, Dept Rheumatol, Seoul, South Korea

[15] Kyung Hee Univ Hosp Gangdong, Dept Rheumatol, Seoul, South Korea

[16] Chonnam Natl Univ, Med Sch & Hosp, Div Rheumatol, Gwangju, South Korea

[17] Kyung Hee Univ Hosp, Dept Internal Med, Div Rheumatol, Seoul, South Korea

[18] Soonchunhyang Univ, Cheonan Hosp, Dept Rheumatol, Cheonan, South Korea

[19] Chungnam Natl Univ Hosp, Dept Rheumatol, Daejeon, South Korea

[20] Korea Univ, Guro Hosp, Div Rheumatol, Seoul, South Korea

[21] Ajou Univ, Sch Med, Dept Rheumatol, Suwon, South Korea

[22] Chonbuk Natl Univ Hosp, Dept Rheumatol, Jeonju, South Korea

[23] Inje Univ, Ilsan Paik Hosp, Dept Internal Med, Div0Rheumatol, Goyang, South Korea

来源：

JOURNAL OF RHEUMATIC DISEASES | 2018年 / 25卷 / 02期

关键词：

Rheumatoid arthritis; Productivity loss; Disease activity score; Patient reported outcome measures;

D O I：

10.4078/jrd.2018.25.2.122

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. Productivity loss was compared by 3-stage of disease activity and associations between higher disease activity and high productivity loss were identified. Methods. Data were extracted from Rheumatoid Arthritis (RA) Patient-reported Outcomes Research, which enrolled 2,000 RA patients (>20-year) on disease-modifying-antirheumatic-drugs (DMARDs) (>= 6-month) from December 2012 to June 2013. This included 1,457 RA patients with the disease activity score (DAS-28-ESR) in their medical charts. Productivity loss in time and indirect cost was estimated using The World Health Organization Health and Work Performance Questionnaire (HPQ). Baseline characteristics and productivity loss outcomes were compared according to DAS-28-ESR groups. Results. 84.4% were females, 54.2% had low DAS-28-ESR (<3.2), and 38.2% and 7.6% had moderate (3.2 similar to 5.1) and high DAS-28-ESR (>5.1). Patients with moderate to high DAS-28-ESR had higher lost productivity time (LPT) and monthly costs of LPT than those with low DAS-28-ESR (time in hours: 110.0 +/- 58.4 vs. 132.4 +/- 57.2 vs. 71.5 +/- 52.0, p<0.0001; monthly costs of LPT in 1,000 Korean won: 1,097 +/- 607 vs. 1,302 +/- 554 vs. 741 +/- 531, p<0.0001). Multiple regression analyses revealed significant associations with high LPT in high (adjusted odds ratio [OR]=3.87, 95% confidence interval [CI]: 2.18 similar to 6.87) and moderate DAS-28-ESR (adjusted OR=1.88, 95% CI: 1.41 similar to 2.52) compared to low DAS-28-ESR. In addition, positive associations with high monthly costs of LPT were observed in high (adjusted OR=3.45, 95% CI: 1.98 similar to 5.99) and moderate DAS-28-ESR (adjusted OR=1.93, 95% CI: 1.43 similar to 2.54) compared to low DAS-28-ESR. Conclusion. Timely therapeutic strategies should be taken into consideration given that the RA patients with moderate to high DAS-28-ESR showed strong associations with high productivity loss for effective management of RA.

引用

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页码：122 / 130

页数：9

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