SULFATIDE AND SULFATIDE ANTIBODIES IN INSULIN-DEPENDENT DIABETES-MELLITUS

被引：53
|
作者：
BUSCHARD, K
JOSEFSEN, K
HORN, T
FREDMAN, P
机构：
[1] MOLNDALS SJUKHUS,DEPT CLIN NEUROSCI,PSYCHIAT & NEUROCHEM SECT,MOLNDAL,SWEDEN
[2] HERLEV HOSP,DEPT PATHOL,DK-2730 HERLEV,DENMARK
来源：
LANCET | 1993年 / 342卷 / 8875期
关键词：
D O I：
10.1016/0140-6736(93)92697-R
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Insulin-dependent diabetes mellitus (IDDM) is associated with neurological disorders. Sulph I, a monoclonal antibody to sulphatide (a neural epitope), stained secretory granules in alpha and beta cells of rat islets of Langerhans, but not exocrine tissue. Sera from 88% of 57 newly diagnosed IDDM patients was anti-sulphatide positive, and 76% were positive 6 months later. All 135 healthy controls were negative. Sulphatide antibody may be an IDDM marker.
引用
收藏
页码：840 / 840
页数：1
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