METHODS FOR THE DETERMINATION OF THE ENANTIOMERIC PURITY OF THE C3-SYNTHONS GLYCIDOL (2,3-EPOXY-1-PROPANOL) AND SOLKETAL [2,2-DIMETYL-4-(HYDROXYMETHYL)-1,3-DIOXOLANE]

被引：13

作者：

GEERLOF, A ^{[1
]}

VANTOL, JBA ^{[1
]}

JONGEJAN, JA ^{[1
]}

DUINE, JA ^{[1
]}

机构：

[1] DELFT UNIV TECHNOL,DEPT MICROBIOL & ENZYMOL,JULIANALAAN 67,2628 BC DELFT,NETHERLANDS

来源：

JOURNAL OF CHROMATOGRAPHY | 1993年 / 648卷 / 01期

关键词：

D O I：

10.1016/0021-9673(93)83293-2

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Accurate and reliable methods are presented for the determination of enantiomeric excess values of glycidol (2,3-epoxy-1-propanol), glycidyl esters, solketal [2,2-dimethyl-4-(hydroxymethyl)-1,3-dioxolane], homologous 1,3-dioxolane alcohols and substituted primary propanols in biological samples. One method consists of derivatization of the samples with 2,3,4,6-tetra-O-acetyl-beta-glucopyranosyl isothiocyanate, followed by separation of the resulting diastereomers on a non-chiral reversed-phase (C18) HPLC column. The second method uses direct injection of (aqueous) samples on to capillary GC columns coated with chiral stationary phases (2,3,6-tri-0-methyl-beta- or a 2,3,6-tri-0-trifluoroacetyl-gamma-cyclodextrin). The advantages and disadvantages of both methods are discussed.

引用

页码：119 / 129

页数：11

共 36 条

[31] STRUCTURE OF POLYESTER MODELS .2. DETERMINATION OF THE OPTIC PURITY OF 1,2 DIBENZOYLOXY PROPANE, 1,3 DIBENZOYLOXY BUTANE, AND 1,4 DIBENZOYLOXY 3-METHYL BUTANE BY C-13 AND H-1-NMR USING CHIRAL SHIFT-REAGENTS
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[32] 2-{(4a′S,6a′S,10a′R,10b′R)-Octahydrospiro[1,3-dioxolane-2,2′-pyrano[2,3-c]chromen]-6a′(1′H)-yloxy}ethanol in the Synthesis of (2S)- and (2R)-Dodecane-1,2-diols
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[33] 2-{(4a′S,6a′S,10a′R,10b′R)-Octahydrospiro[1,3-dioxolane-2,2′-pyrano[2,3-c]chromen]-6a′(1′H)-yloxy}ethanol in the Synthesis of (2S)- and (2R)-Dodecane-1,2-diols
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[34] 1H and 13C NMR determination of the enantiomeric purity of substituted 4-amino-3-(thien-2-yl)-butyric acids and 4-amino-3-(benzo[b]furan-2-yl)-butyric acids, ligands of the GABAB receptor.
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[35] APPROACHES TO THE ASSEMBLY OF THE ANTIFUNGAL AGENT FR-900848 - STUDIES ON THE SYNTHESIS OF C-2 SYMMETRICAL TETRACYCLOPROPANE DERIVATIVES AND AN X-RAY CRYSTALLOGRAPHIC STUDY OF (1R,3S,4S,6R)-BICYCLOPROPYL-1,6-DI-(2-[(4R,5R)-DI(ISOPROPYLOXYCARBONYL)-1,3-DIOXOLANE])
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[36] Quantitative determination of 4-ethoxy-2-[2-hydroxy-3-(4-phenyl-1-piperazinyl)]propyl-2,3-dihydro-6-methyl-1,3-dioxo-1H-pyrrolo-[3,4-c]pyridine applying high-performance liquid chromatography with UV detection. Studies on degradation mechanism
Muszalska, I
Sladowska, H
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CHEMIA ANALITYCZNA, 2005, 50 (05): : 875 - 886

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