Hybrid process modeling for advanced process state estimation, prediction, and control exemplified in a production-scale mammalian cell culture

被引：0
|
作者：
Dors, M
Simutis, R
Lubbert, A
机构：
来源：
BIOSENSOR AND CHEMICAL SENSOR TECHNOLOGY: PROCESS MONITORING AND CONTROL | 1995年 / 613卷
关键词：
D O I：
暂无
中图分类号：
TQ [化学工业];
学科分类号：
0817 ;
摘要：
Indirect measurements, process state predictions and optimization can be largely improved by exploiting all available knowledge and data about a given production process. This concept has been implemented in an industrial process producing a recombinant protein in mammalian cell culture. The model has been used for indirect measurements and optimization of feeding profiles and was directly used for process control.
引用
收藏
页码：144 / 154
页数：11
相关论文
共 50 条
  • [41] BIOT 280-Development and scale-up of perfusion cell culture process for therapeutic protein production
    Luo, Jun
    Bedard, Charles
    Lin, WengLong
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 232
  • [42] PRODUCTION OF RABIES VACCINE BY AN INDUSTRIAL-SCALE BHK-21 SUSPENSION CELL-CULTURE PROCESS
    PAY, TWF
    BOGE, A
    MENARD, FJRR
    RADLETT, PJ
    DEVELOPMENTS IN BIOLOGICAL STANDARDIZATION, 1985, 60 : 171 - 174
  • [43] Advanced operation and control in graphical user interface of a membrane-integrated hybrid biochemical process for acetic acid production
    Nayak, Jayato
    Pal, Parimal
    Chakrabortty, Sankha
    Dey, Pinaki
    Kumar, Ramesh
    Banerjee, Shirsendu
    Antony, Jenish Soosai
    INDIAN CHEMICAL ENGINEER, 2021, 63 (01) : 84 - 98
  • [44] Model Transferability and Reduced Experimental Burden in Cell Culture Process Development Facilitated by Hybrid Modeling and Intensified Design of Experiments
    Bayer, Benjamin
    Duerkop, Mark
    Striedner, Gerald
    Sissolak, Bernhard
    FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2021, 9
  • [45] Model Transferability and Reduced Experimental Burden in Cell Culture Process Development Facilitated by Hybrid Modeling and Intensified Design of Experiments
    Bayer, Benjamin
    Duerkop, Mark
    Striedner, Gerald
    Sissolak, Bernhard
    Frontiers in Bioengineering and Biotechnology, 2021, 9
  • [46] CO2 control strategy at 3L bench scale for cell culture process development and scale-up
    Russell, Brian
    Hahn, Kathryn
    Ahuja, Sanjeev
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 257
  • [47] Evaluation of process tools used to monitor and control the production of virus-like particles in insect cell culture
    Cacciuttolo, MA
    Patchan, M
    Tsao, E
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1997, 213 : 156 - BIOT
  • [48] Genome scale metabolic modeling of recombinant protein producing yeasts: prediction of process parameters and metabolic engineering targets for efficient production
    Mattanovich, Diethard
    NEW BIOTECHNOLOGY, 2014, 31 : S29 - S29
  • [49] A three-step machine learning framework for energy profiling, activity state prediction and production estimation in smart process manufacturing
    Tan, Daniel
    Suvarna, Manu
    Tan, Yee Shee
    Li, Jie
    Wang, Xiaonan
    APPLIED ENERGY, 2021, 291
  • [50] Effect of ambient light on monoclonal antibody product quality during small-scale mammalian cell culture process in clear glass bioreactors
    Mallaney, Mary
    Wang, Szu-han
    Sreedhara, Alavattam
    BIOTECHNOLOGY PROGRESS, 2014, 30 (03) : 562 - 570
12345