LOCALIZATION OF THE ALPHA-LIKE GLOBIN GENE-CLUSTER TO REGION Q12 OF RABBIT CHROMOSOME-6 BY INSITU HYBRIDIZATION

被引：17
|
作者：
XU, J [1 ]
HARDISON, RC [1 ]
机构：
[1] PENN STATE UNIV,DEPT MOLEC & CELL BIOL,206 ALTHOUSE LAB,UNIVERSITY PK,PA 16802
来源：
GENOMICS | 1991年 / 9卷 / 02期
关键词：
D O I：
10.1016/0888-7543(91)90265-G
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The rabbit (Oryctolagus cuniculus) α-like globin gene cluster (HBAC) contains several block duplications of ζ-, α-, and θ-globin genes. Using in situ hybridizations to metaphase chromosome spreads, the gene cluster has been mapped to region q12 of chromosome 6. Given that human HBAC maps to the short arm of chromosome 16, the mapping of rabbit HBAC to 6q12 confirms the assignment of homology between OCU6q and HSA16p based on similarities of chromosomal banding patterns. In both species, HBAC is in a very G+C-rich region within the most distal band of the chromosome. © 1991.
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收藏
页码：362 / 365
页数：4
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