TRANSCRIPTIONAL ACTIVITY OF THE PHOSPHOENOLPYRUVATE CARBOXYKINASE GENE DECREASES IN REGENERATING RAT-LIVER

被引：6
|
作者：
MILLAND, J
SCHREIBER, G
机构：
[1] The Russel Grimwade School of Biochemistry, University of Melbourne, Parkville
来源：
FEBS LETTERS | 1991年 / 279卷 / 02期
关键词：
PHOSPHOENOLPYRUVATE CARBOXYKINASE; REGENERATING LIVER; PARTIAL HEPATECTOMY; TRANSCRIPTIONAL ACTIVITY; MESSENGER RNA LEVEL; GLUCONEOGENESIS;
D O I：
10.1016/0014-5793(91)80144-R
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Rat cytosolic phosphoenolpyruvate carboxykinase (PEPCK) gene expression and enzyme activity in liver were studied in rats fasted for 12 hours before and after partial hepatectomy, sham operation or no operation. Transcriptional activity and mRNA levels decreased in regenerating liver compared to sham-operated and unoperated controls. In contrast, PEPCK enzyme activity in regenerating liver was similar to that in the livers of sham-operated and unoperated controls. Since all the animals were fasted the decrease in transcription is probably caused by some factor other than insulin, the known repressor of PEPCK gene expression.
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页码：184 / 186
页数：3
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