The aim of the article is to consider the Soviet system of scientific and technical information, to find out its peculiarities, to follow up its structural and functional changes proceeded in its central and regional (Eastern) institutes under the influence of technological revolution and changes happening in the USSR in the second half of the 1950ss and the first half of 1960ss. The research source base includes edited and inedited periodical press documents and materials. Useful and important documents were withdrawn from central archive funds: the archive of the Exhibition of Economic Achievements (VDNKh), The State Archive of the Russian Federation (SARF), the Central Archive of the All-Union Central Trade Union Council (CA AUCTU) and local archives: the State Archives of Altai territory (SAAT), the State Archive of Kemerovo, Novosibirsk, Omsk, Tomsk regions (SAKR, SANR, SAOR, SATR). They helped to find out and discover principal problems of the subject, the fundamental conceptual ideas of the developed and presented subject were confirmed by the factual basis. It can be seen from the contents given below. In the beginning of the second part of XX century, when the USSR accepted the technological revolution and engaged in its process, the information system transformed and acquired new institutes, including such an important one as All-Union Institute of Scientific and Technical Information, which added mobile, scientific, systemic character to the country's communication system and allowed it to overcome information vacuum. The sphere of regional information evolved. Scientific and technical information centers, public universities and institutes of technical progress, public technical information bureaus at some enterprises were established. However, such structural and other transformation within the information field had also negative effects for its further operation. On the basis of the performed studies, we can summarize that in the reviewed period the USSR information system transformed particularly, recovered from series of restrictions and regulatory activities passed on Stalinism, acquired new structures, enlarged and strengthened its staffing, made contacts with foreign information carriers. But it also kept certain problems and the most significant of them are the absence of proper coordination between different information structures and clear mechanism for targeting and implementing of the proposed technical novelties and improvements, and as the results, the decrease of staff interest to information resources and innovations.