SYNTHESIS OF [119MSN]-MESOPORPHYRIN-IX DICHLORIDE

被引：1
|
作者：
DENISSEN, JF
机构：
[1] Biotransformation Section, Drug Metabolism Department, Abbott Laboratories, Illinois, 60064, Abbott Park
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1990年 / 28卷 / 12期
关键词：
D O I：
10.1002/jlcr.2580281210
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Tin mesoporphyrin IX dichloride (Sn‐MPCl2) is a heme oxygenase inhibitor of current clinical interest for the treatment of neonatal hyperbilirubinemia. The synthesis of [119mSn]‐MPCl2 for drug metabolism and disposition studies is reported. [119mSn]‐MPCl2 was prepared in 60% radiochemical yield by metalation of the porphyrin nucleus of mesoporphyrin IX dihydrochloride with tin(II)‐119m acetate. The product had a specific activity of 43.4 mCi/mmol and a radiochemical purity of 99%, as determined by radio‐HPLC analysis. Copyright © 1990 John Wiley & Sons, Ltd.
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页码：1421 / 1426
页数：6
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