STIMULATION OF PROTEIN-KINASE-C BY 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN (TCDD) IN RAT THYMOCYTES

被引：19
|
作者：
DEPETRILLO, PB
KURL, RN
机构：
[1] BROWN UNIV,SCH MED,PROGRAM CLIN PHARMACOL,PROVIDENCE,RI 02912
[2] BROWN UNIV,SCH MED,GRAD PROGRAM PATHOBIOL,PROVIDENCE,RI 02912
来源：
TOXICOLOGY LETTERS | 1993年 / 69卷 / 01期
关键词：
2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN; THYMOCYTE; PROTEIN KINACE-C; CYTOSOL;
D O I：
10.1016/0378-4274(93)90142-K
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Exposure of immature thymocytes to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (10 nM) transiently increased detergent extractable protein kinase C (PKC) activity. The increase was apparent at 7.5 min after exposure of cells to TCDD. At later time points, PKC activity returned to control values. Addition of TCDD to cytosol significantly increased phospholipid-stimulated PKC activity. Thus, stimulation of PKC activity may be one of the early events affected by TCDD.
引用
收藏
页码：31 / 36
页数：6
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