TUNICAMYCIN-INDUCED INHIBITION OF FUNCTIONAL EXPRESSION OF GLUTAMATE RECEPTORS IN XENOPUS OOCYTES

被引：0
|
作者：
MUSSHOFF, U [1 ]
MADEJA, M [1 ]
BLOMS, P [1 ]
MUSCHNITTEL, K [1 ]
SPECKMANN, EJ [1 ]
机构：
[1] INST EXPTL EPILEPSIEFORSCH,MUNSTER,GERMANY
来源：
NEUROSCIENCE LETTERS | 1992年 / 147卷 / 02期
关键词：
TUNICAMYCIN; N-GLYCOSYLATION; GLUTAMATE RECEPTOR; MEMBRANE CURRENT; XENOPUS-LAEVIS; OOCYTE;
D O I：
暂无
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effects of tunicamycin, a specific inhibitor of N-linked glycosylation, on functional expression of glutamate receptor subtypes were investigated in RNA-injected oocytes. In the presence of tunicamycin the expression of ligand-operated receptors sensitive to kainate, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) and quisqualate were completely blocked. The inhibitory effect was reversible after removal of tunicamycin from the culture medium.
引用
收藏
页码：163 / 166
页数：4
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