G-308A polymorphism in the tumor necrosis factor-alpha gene in Buryats

被引：0
|
作者：
Dugarova, G. O. [1 ]
Golubenko, M., V [2 ]
Eremina, E. R. [3 ]
Minaycheva, L., I [4 ]
Fadyushina, S., V [5 ]
机构：
[1] Childrens Republican Clin Hosp, Moscow Childrens Clin Hosp, Ulan Ude, Russia
[2] Russian Acad Med Sci, Res Inst Med Genet, Siberian Branch, Tomsk, Russia
[3] SRI MGSS RAMS, Buryat Branch, Ulan Ude, Russia
[4] Res Inst MG SB RAMS, Tomsk, Russia
[5] MG SB RAMS, Moscow Res Inst, Moscow, Russia
来源：
YAKUT MEDICAL JOURNAL | 2009年 / 02期
关键词：
polymorphism; the tumor necrosis factor-alpha gene; Buryats;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
G-308A polymorphism in the tumor necrosis factor-alpha (TNF) gene has been studied in the Buryat population by genotyping samples from 16 subpopulations from 5 areas of Republic Buryatiya (N=865). The TNF-alpha G-308A polymorphism was assessed by the PCR and restriction analysis. It has been shown that frequency of the A allele in Buryats was 11.5 %. At comparison with other Siberian populations, statistically significant differences with Yakuts were found. In several subpopulations the deviation of genotype frequencies from Hardy-Weinberg equilibrium was revealed. Calculation of genetic differentiation measure for all settlements (Gst=0.0167) and for 5 investigated areas (Gst=0.0053) did not demonstrate significant differentiation of a gene pool of Buryats by the given polymorphism. The results give for Buryat population the characteristics of prevalence of functionally significant polymorphism for which associations with various multifactorial diseases are known.
引用
收藏
页码：127 / 129
页数：3
相关论文
共 50 条
  • [31] Association of Tumor Necrosis Factor-α Gene G-308A Polymorphism with Dilated Cardiomyopathy: A Meta-Analysis
    Luo, Rong
    Li, Xiaoping
    Fan, Xiongwei
    Yuan, Wuzhou
    Wu, Xiushan
    DNA AND CELL BIOLOGY, 2013, 32 (03) : 130 - 137
  • [32] Polymorphism G-308A in the promoter of the tumor necrosis factor-α gene and its association with the risk of venous thromboembolism
    Horakova, Kristyna
    Chylkova, Alicja
    Kolorz, Michal
    Bartosova, Ladislava
    Pechacek, Vaclav
    Starostka, David
    Wroblova, Katerina
    BLOOD COAGULATION & FIBRINOLYSIS, 2012, 23 (04) : 316 - 319
  • [33] The role of tumor necrosis factor alpha G-308A polymorphisms in the course of pulmonary sarcoidosis
    Wijnen, P. A.
    Nelemans, P. J.
    Verschakelen, J. A.
    Bekers, O.
    Voorter, C. E.
    Drent, M.
    TISSUE ANTIGENS, 2010, 75 (03): : 262 - 268
  • [34] The Association between Tumor Necrosis Factor-alpha Polymorphism (-308, G/A) and Acute Solid Organ Rejection
    Park, Min-Su
    TRANSPLANTATION, 2016, 100 : S210 - S210
  • [35] The Association Between the Tumor Necrosis Factor-Alpha Gene-308A/G Polymorphism and Chronic Pancreatitis: A Meta-Analysis
    Zhang, Xiao-qin
    Pan, Ling-ai
    He, Hong-li
    Liu, Rong-an
    Wu, Xiao-xiao
    Huang, Xiao-bo
    GENETIC TESTING AND MOLECULAR BIOMARKERS, 2020, 24 (01) : 33 - 37
  • [36] Tumor necrosis factor-alpha gene −308G > A polymorphism alters the risk of hepatocellular carcinoma in a Han Chinese population
    Hua Feng
    Jing-hua Kuai
    Ming-yan Zhang
    Guang-chuan Wang
    Yong-jun Shi
    Jun-yong Zhang
    Diagnostic Pathology, 9
  • [37] Tumor necrosis factor alpha gene G-308A polymorphism, insulin resistance, and fasting plasma glucose in young, older, and diabetic Japanese men
    Ishii, T
    Hirose, H
    Saito, I
    Nishikai, K
    Maruyama, H
    Saruta, T
    METABOLISM-CLINICAL AND EXPERIMENTAL, 2000, 49 (12): : 1616 - 1618
  • [38] Tumor necrosis factor-α gene G-308A polymorphism, insulin resistance, and fasting plasma glucose in Japanese men
    Ishii, T
    Hirose, H
    Nishikai, K
    Maruyama, H
    Saito, I
    DIABETES, 2000, 49 : A398 - A398
  • [39] Tumor necrosis factor-alpha gene promoter polymorphism in schizophrenia
    Rybakowski, F
    Czerski, P
    Kapelski, P
    Godlewski, S
    Dmitrzak-Weglarz, M
    Hauser, J
    Rybakowski, J
    AMERICAN JOURNAL OF MEDICAL GENETICS, 2002, 114 (07): : 805 - 805
  • [40] Tumor necrosis factor-alpha gene polymorphism in chronic bronchitis
    Huang, SL
    Su, CH
    Chang, SC
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1997, 156 (05) : 1436 - 1439
12345