CELLULAR-LOCALIZATION OF SEROTONIN TRANSPORTER MESSENGER-RNA IN THE RAT-BRAIN

被引：69
|
作者：
FUJITA, M [1 ]
SHIMADA, S [1 ]
MAENO, H [1 ]
NISHIMURA, T [1 ]
TOHYAMA, M [1 ]
机构：
[1] OSAKA UNIV,SCH MED,DEPT ANAT & NEUROSCI,SUITA,OSAKA 565,JAPAN
来源：
NEUROSCIENCE LETTERS | 1993年 / 162卷 / 1-2期
关键词：
SEROTONIN TRANSPORTER MESSENGER RNA; IN-SITU HYBRIDIZATION HISTOCHEMISTRY; RAPHE NUCLEUS;
D O I：
10.1016/0304-3940(93)90559-4
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Expression of serotonin (5-hydroxytryptamine, 5-HT) transporter mRNA in the rat brain was examined by in situ hybridization histochemistry with a synthetic oligonucleotide probe. 5-HT transporter mRNA was expressed in neurons in most of the raphe nuclei. The dorsal and median raphe nuclei contained intensely labeled neurons, while the caudal linear nucleus, raphe magnus nucleus, raphe pontis nucleus, raphe pallidus nucleus and the raphe obscurus nucleus contained weakly or moderately labeled neurons. The localization pattern of the 5-HT transporter mRNA-positive neurons coincides fairly well with that of 5-HT-immunoreactive neurons, indicating that 5-HT transporter is primarily located in serotonergic neurons.
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收藏
页码：59 / 62
页数：4
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