CELLULAR-LOCALIZATION OF SEROTONIN TRANSPORTER MESSENGER-RNA IN THE RAT-BRAIN

被引：69
|
作者：
FUJITA, M [1 ]
SHIMADA, S [1 ]
MAENO, H [1 ]
NISHIMURA, T [1 ]
TOHYAMA, M [1 ]
机构：
[1] OSAKA UNIV,SCH MED,DEPT ANAT & NEUROSCI,SUITA,OSAKA 565,JAPAN
来源：
NEUROSCIENCE LETTERS | 1993年 / 162卷 / 1-2期
关键词：
SEROTONIN TRANSPORTER MESSENGER RNA; IN-SITU HYBRIDIZATION HISTOCHEMISTRY; RAPHE NUCLEUS;
D O I：
10.1016/0304-3940(93)90559-4
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Expression of serotonin (5-hydroxytryptamine, 5-HT) transporter mRNA in the rat brain was examined by in situ hybridization histochemistry with a synthetic oligonucleotide probe. 5-HT transporter mRNA was expressed in neurons in most of the raphe nuclei. The dorsal and median raphe nuclei contained intensely labeled neurons, while the caudal linear nucleus, raphe magnus nucleus, raphe pontis nucleus, raphe pallidus nucleus and the raphe obscurus nucleus contained weakly or moderately labeled neurons. The localization pattern of the 5-HT transporter mRNA-positive neurons coincides fairly well with that of 5-HT-immunoreactive neurons, indicating that 5-HT transporter is primarily located in serotonergic neurons.
引用
收藏
页码：59 / 62
页数：4
相关论文
共 50 条
  • [1] THE SEMIQUANTITATIVE DISTRIBUTION AND CELLULAR-LOCALIZATION OF ANGIOTENSINOGEN MESSENGER-RNA IN THE RAT-BRAIN
    BUNNEMANN, B
    FUXE, K
    METZGER, R
    BJELKE, B
    GANTEN, D
    [J]. JOURNAL OF CHEMICAL NEUROANATOMY, 1992, 5 (03) : 245 - 262
  • [2] CELLULAR-LOCALIZATION OF GAP JUNCTION MESSENGER-RNA IN THE NEONATAL RAT-BRAIN
    MATSUMOTO, A
    ARAI, Y
    URANO, A
    HYODO, S
    [J]. NEUROSCIENCE LETTERS, 1991, 124 (02) : 225 - 228
  • [3] DISTRIBUTION AND CELLULAR-LOCALIZATION OF DARPP-32 MESSENGER-RNA IN RAT-BRAIN
    SCHALLING, M
    DJURFELDT, M
    HOKFELT, T
    EHRLICH, M
    KURIHARA, T
    GREENGARD, P
    [J]. MOLECULAR BRAIN RESEARCH, 1990, 7 (02): : 139 - 149
  • [4] CELLULAR-LOCALIZATION OF INTERLEUKIN-6 MESSENGER-RNA AND INTERLEUKIN-6 RECEPTOR MESSENGER-RNA IN RAT-BRAIN
    SCHOBITZ, B
    DEKLOET, ER
    SUTANTO, W
    HOLSBOER, F
    [J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 1993, 5 (11) : 1426 - 1435
  • [5] SEROTONIN DEPLETION DECREASES SEROTONIN TRANSPORTER MESSENGER-RNA LEVELS IN RAT-BRAIN
    LINNET, K
    KOED, K
    WIBORG, O
    GREGERSEN, N
    [J]. BRAIN RESEARCH, 1995, 697 (1-2) : 251 - 253
  • [6] SEROTONIN TRANSPORTER MESSENGER-RNA IN RAT-BRAIN IS REGULATED BY CLASSICAL ANTIDEPRESSANTS
    LOPEZ, JF
    CHALMERS, DT
    VAZQUEZ, DM
    WATSON, SJ
    AKIL, H
    [J]. BIOLOGICAL PSYCHIATRY, 1994, 35 (04) : 287 - 290
  • [7] CELLULAR-LOCALIZATION OF SOMATOSTATIN MESSENGER-RNA IN RAT RETINA
    YAMAGUCHI, K
    GAUR, VP
    SPIRA, AW
    TURNER, JE
    [J]. NEUROPEPTIDES, 1990, 17 (01) : 13 - 16
  • [8] CELLULAR-LOCALIZATION OF THROMBIN RECEPTOR MESSENGER-RNA IN RAT-BRAIN - EXPRESSION BY MESENCEPHALIC DOPAMINERGIC-NEURONS AND CODISTRIBUTION WITH PROTHROMBIN MESSENGER-RNA
    WEINSTEIN, JR
    GOLD, SJ
    CUNNINGHAM, DD
    GALL, CM
    [J]. JOURNAL OF NEUROSCIENCE, 1995, 15 (04): : 2906 - 2919
  • [9] REGIONAL DISTRIBUTION, DEVELOPMENTAL-CHANGES, AND CELLULAR-LOCALIZATION OF CNTF MESSENGER-RNA AND PROTEIN IN THE RAT-BRAIN
    STOCKLI, KA
    LILLIEN, LE
    NAHERNOE, M
    BREITFELD, G
    HUGHES, RA
    RAFF, MC
    THOENEN, H
    SENDTNER, M
    [J]. JOURNAL OF CELL BIOLOGY, 1991, 115 (02): : 447 - 459
  • [10] THE CELLULAR-LOCALIZATION OF MESSENGER-RNA IN NEUROBIOLOGY
    HUNT, SP
    GOEDERT, M
    [J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 1987, 15 (01) : 133 - 133
12345