GAS-CHROMATOGRAPHIC ASSAY OF VIGABATRIN ENANTIOMERS IN PLASMA

被引：31
|
作者：
SCHRAMM, TM [1 ]
MCKINNON, GE [1 ]
EADIE, MJ [1 ]
机构：
[1] UNIV QUEENSLAND,QUEENSLAND AGR BIOTECHNOL CTR,ST LUCIA,QLD 4067,AUSTRALIA
来源：
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1993年 / 616卷 / 01期
关键词：
D O I：
10.1016/0378-4347(93)80469-K
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A rapid and specific gas chromatographic method has been developed for the determination of plasma R(-)- and S(+)-vigabatrin concentrations. The method involves a double derivatisation step, chromatography on a megabore Chirasil-Val capillary column and thermionic specific detection. Concentrations in the range 1.0-200 mug/ml can be measured for R(-)-vigabatrin, and 0.5-100 mug/ml for S(+)-vigabatrin, using 250 mul of plasma. The assay is suitable for pharmacokinetic studies and routine therapeutic drug monitoring in humans.
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页码：39 / 44
页数：6
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