THE PROTEIN-KINASE-C AND PROTEIN-KINASE-C RELATED GENE FAMILIES

被引：106
|
作者：
DEKKER, LV
PALMER, RH
PARKER, PJ
机构：
来源：
CURRENT OPINION IN STRUCTURAL BIOLOGY | 1995年 / 5卷 / 03期
关键词：
D O I：
10.1016/0959-440X(95)80103-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Protein kinase C is an important target enzyme for lipid second messengers. Recent developments have focused on the tertiary structure analysis of domains present in protein kinase C and in combination with functional approaches such as mutagenesis and domain expression have generated a detailed understanding of the modular mechanism by which lipids cause activation. This provides a reference for the study of the protein kinase C-related kinases, a recently identified new class of kinases that are highly related to protein kinase C in their catalytic characteristics but have distinct regulatory features.
引用
收藏
页码：396 / 402
页数：7
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