HIGH-AFFINITY AND LOW-AFFINITY STATES OF DOPAMINE D(1) RECEPTORS IN SCHIZOPHRENIA

被引：10

作者：

MAMELAK, M

CHIU, S

MISHRA, RK

机构：

[1] SUNNYBROOK MED CTR, DEPT PSYCHIAT, TORONTO M4N 3M5, ONTARIO, CANADA

[2] MCMASTER UNIV, MED CTR, DEPT PSYCHIAT, NEUROPHARMACOL LAB, HAMILTON L8N 3Z5, ONTARIO, CANADA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 233卷 / 01期

关键词：

SCHIZOPHRENIA; AFFINITY STATES; DOPAMINE D(1) RECEPTORS;

D O I：

10.1016/0014-2999(93)90366-P

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Using SKF-38393/[H-3]SCH-23390 dopamine D1 receptor agonist/antagonist competition binding technique, we showed that schizophrenics distinguished from the neuro-psychiatric and normal controls by exhibiting a significant increase in the density of the low-affinity state, and a concomitant enhancement in the binding affinity of the high-affinity state of D1 dopamine receptors in caudate nucleus. The results suggest that perturbation in dynamic equilibrium of high- and low-affinity states of D1 receptors underlies the pathogenesis of schizophrenia.

引用

页码：175 / 176

页数：2

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