MODULATION OF DOXORUBICIN-TOXICITY BY TAMOXIFEN IN MULTIDRUG-RESISTANT TUMOR-CELLS IN-VITRO AND IN-VIVO

被引：14
|
作者：
POMMERENKE, E [1 ]
MATTERN, J [1 ]
VOLM, M [1 ]
机构：
[1] GERMAN CANC RES CTR,D-69009 HEIDELBERG,GERMANY
来源：
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 1994年 / 120卷 / 07期
关键词：
MULTIDRUG-RESISTANCE; CIRCUMVENTION OF RESISTANCE; SOLID TUMORS;
D O I：
10.1007/BF01240142
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Modulation of the resistance of tumors offers new strategies to improve the therapeutical treatment of cancer. In this report, the anti-oestrogen tamoxifen was investigated in multidrug-resistant tumor cells in vitro and in vivo. The doxorubicin-resistance of L 1210/DOX-tumor cells, which express the multidrug-resistance phenotype, could be completely circumvented by addition of 1 mu g/ml tamoxifen. In contrast, no increased effect could be observed in the parental L 1210 tumor cells or in cytosine arabinoside-resistant L 1210 cells not expressing the multidrug-resistance phenotype. Thus, the enhancing effect of tamoxifen was restricted only to the multidrug-resistant L 1210/DOX tumor cells. Similar to the in vitro experiments, a significant reduction in the growth in solid tumors of mice by the combined treatment of doxorubicin and tamoxifen was again observed only in the multidrug-resistant L 1210/DOX tumors.
引用
收藏
页码：422 / 426
页数：5
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