RECOGNITION OF SIZE AND CHARGED STATES OF ANTIGENS BY ANTIPEPTIDE ANTIBODIES

被引：3
|
作者：
SOHMA, Y [1 ]
ATSUSHI, M [1 ]
MORITA, H [1 ]
KATOH, S [1 ]
SADA, E [1 ]
机构：
[1] KYOTO UNIV,FAC ENGN,DEPT CHEM ENGN,SAKYO KU,KYOTO 606,JAPAN
来源：
JOURNAL OF FERMENTATION AND BIOENGINEERING | 1992年 / 73卷 / 06期
关键词：
D O I：
10.1016/0922-338X(92)90132-E
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The effects of the size and characteristics of peptide antigens on recognition and equilibrium between antigens and antibodies were studied by immunization of peptides with different characteristics. Four to five residues in the peptides were recognized by antibodies, and the charged states of the residues in the epitope strongly affected the immunointeraction. These results suggest a guideline for the selection of antigenic determinants to obtain antibodies suitable for immunoaffinity chromatography.
引用
收藏
页码：431 / 434
页数：4
相关论文
共 50 条
  • [31] RECOGNITION OF TUMOR-ASSOCIATED ANTIGENS BY HUMAN MONOCLONAL-ANTIBODIES
    IMAM, A
    TOKES, ZA
    TAYLOR, CR
    IMMUNOLOGICAL COMMUNICATIONS, 1983, 12 (01): : 63 - 63
  • [32] ANTIPEPTIDE ANTIBODIES THAT RECOGNIZE A LYMPHOCYTE SUBSTANCE-P RECEPTOR
    PASCUAL, DW
    BLALOCK, JE
    BOST, KL
    JOURNAL OF IMMUNOLOGY, 1989, 143 (11): : 3697 - 3702
  • [33] Antibodies to pituitary surface antigens during various pituitary disease states
    Keda, YM
    Krjukova, IV
    Ilovaiskaia, IA
    Morozova, MS
    Fofanova, OV
    Babarina, MB
    Marova, EI
    Pankov, YA
    Kandror, VI
    JOURNAL OF ENDOCRINOLOGY, 2002, 175 (02) : 417 - 423
  • [34] ANTIPEPTIDE ANTIBODIES AGAINST A TORPEDO CYSTEINE-STRING PROTEIN
    MASTROGIACOMO, A
    EVANS, CJ
    GUNDERSEN, CB
    JOURNAL OF NEUROCHEMISTRY, 1994, 62 (03) : 873 - 880
  • [35] Antibacterial and antipeptide antibodies in Japanese and Finnish patients with rheumatoid arthritis
    Rashid, T
    Leirisalo-Repo, M
    Tani, Y
    Hukuda, S
    Kobayashi, S
    Wilson, C
    Bansal, S
    Ebringer, A
    CLINICAL RHEUMATOLOGY, 2004, 23 (02) : 134 - 141
  • [36] THE PHYSICAL BASIS FOR INDUCTION OF PROTEIN-REACTIVE ANTIPEPTIDE ANTIBODIES
    DYSON, HJ
    LERNER, RA
    WRIGHT, PE
    ANNUAL REVIEW OF BIOPHYSICS AND BIOPHYSICAL CHEMISTRY, 1988, 17 : 305 - 324
  • [37] DEVELOPMENT OF ANTIPEPTIDE ANTIBODIES SPECIFIC FOR EPIDERMAL SURFACE-ANTIGEN
    SCHROEDER, WT
    DANIELSON, M
    BURLINGAME, S
    CLINICAL RESEARCH, 1993, 41 (04): : A777 - A777
  • [38] ANTIPEPTIDE MONOCLONAL-ANTIBODIES TO INTESTINAL MUCIN-3
    APOSTOLOPOULOS, V
    XING, PX
    MCKENZIE, IFC
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 1995, 10 (05) : 555 - 561
  • [39] PRODUCTION OF ANTIPEPTIDE ANTIBODIES IN RABBITS AND CHICKENS - A COMPARATIVE-STUDY
    JARNOT, M
    VANDERKLOK, MA
    CORBETT, AM
    BIOPHYSICAL JOURNAL, 1994, 66 (02) : A28 - A28
  • [40] RABBIT ANTIPEPTIDE ANTIBODIES AGAINST RESTRICTED DOMAINS OF THE HISTOCOMPATIBILITY COMPLEX
    CHERSI, A
    HOUGHTEN, RA
    ZEITSCHRIFT FUR NATURFORSCHUNG C-A JOURNAL OF BIOSCIENCES, 1984, 39 (06): : 646 - 651
12345