FAS AND PERFORIN PATHWAYS AS MAJOR MECHANISMS OF T-CELL-MEDIATED CYTOTOXICITY

被引：1436

作者：

KAGI, D

VIGNAUX, F

LEDERMANN, B

BURKI, K

DEPRAETERE, V

NAGATA, S

HENGARTNER, H

GOLSTEIN, P

机构：

[1] CNRS MARSEILLE LUMINY,INSERM,CTR IMMUNOL,F-13288 MARSEILLE 9,FRANCE

[2] UNIV ZURICH,INST EXPTL IMMUNOL,DEPT PATHOL,CH-8091 ZURICH,SWITZERLAND

[3] SANDOZ PHARMA LTD,PRECLIN RES,CH-4002 BASEL,SWITZERLAND

[4] OSAKA BIOSCI INST,SUITA,OSAKA 565,JAPAN

来源：

SCIENCE | 1994年 / 265卷 / 5171期

关键词：

D O I：

10.1126/science.7518614

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Two molecular mechanisms of T cell-mediated cytotoxicity, one perforin-based, the other Fas-based, have been demonstrated. To determine the extent of their contribution to T cell-mediated cytotoxicity, a range of effector cells from normal control or perforin-deficient mice were tested against a panel of target cells with various levels of Fas expression. All cytotoxicity observed was due to either of these mechanisms, and no third mechanism was detected. Thus, the perforin- and Fas-based mechanisms may account for all T cell-mediated cytotoxicity in short-term in vitro assays.

引用

页码：528 / 530

页数：3

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