CLASSICAL CONDITIONING-INDUCED CHANGES IN LOW-MOLECULAR-WEIGHT GTP-BINDING PROTEINS IN RABBIT HIPPOCAMPUS

被引：11

作者：

NELSON, TJ

SANCHEZANDRES, JV

SCHREURS, BG

ALKON, DL

机构：

[1] National Institute of Neurological Disorders and Stroke, Laboratory of Molecular and Cellular Neurobiology, Section on Neural Systems, National Institutes of Health, Bethesda, Maryland

来源：

JOURNAL OF NEUROCHEMISTRY | 1991年 / 57卷 / 06期

关键词：

CYTOSOL; PARTICULATE FRACTION; CA1; HIPPOCAMPUS; CONDITIONED STIMULUS; ASSOCIATIVE LEARNING; PROTOONCOGENE;

D O I：

10.1111/j.1471-4159.1991.tb06423.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Classical conditioning of Hermissenda, involving paired light-rotation events, results in a 30-35% decrease in the levels of a 20-kDa G protein (cp20). To test whether a similar protein exists in vertebrates, rabbits were trained to associate a tone with periorbital electrical stimulation and G proteins were analyzed by photoaffinity labeling with [alpha-P-32]GTP-azidoanilide. A 20-kDa G protein similar to cp20 decreased by 36% in the hippocampus of rabbits subjected to paired tone and electrical stimulation, but not in unpaired controls. Learning-specific decreases were also found in the amount of ras protein.

引用

页码：2065 / 2069

页数：5

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