SYNERGISTIC EFFECT OF GANCICLOVIR AND FOSCARNET ON CYTOMEGALOVIRUS REPLICATION INVITRO

被引：109
|
作者：
MANISCHEWITZ, JF [1 ]
QUINNAN, GV [1 ]
LANE, HC [1 ]
WITTEK, AE [1 ]
机构：
[1] NIAID,CLIN IMMUNOL LAB,BETHESDA,MD 20892
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1990年 / 34卷 / 02期
关键词：
D O I：
10.1128/AAC.34.2.373
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Ganciclovir and foscarnet possess substantial activity against cytomegalovirus. Both exhibit dose-limiting toxicity, which reduces their clinical usefulness. We demonstrated synergistic inhibition of cytomegalovirus replication in vitro by ganciclovir and foscarnet. Reduced-dose combination therapy may provide a means to treat patients with cytomegalovirus infection while reducing drug toxicity.
引用
收藏
页码：373 / 375
页数：3
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