ABNORMALITIES OF CHROMOSOME 22 IN MENINGIOMAS AND CONFIRMATION OF THE ORIGIN OF A DICENTRIC 22 BY INSITU HYBRIDIZATION

被引：12
|
作者：
TONK, V
OSELLA, P
DELASMORENAS, A
WYANDT, HE
MILUNSKY, A
机构：
[1] BOSTON UNIV,SCH MED,CTR HUMAN GENET,80 E CONCORD ST,BOSTON,MA 02118
[2] BOSTON UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02118
[3] BOSTON UNIV,SCH MED,DEPT PEDIAT,BOSTON,MA 02118
[4] BOSTON UNIV,SCH MED,DEPT OBSTET & GYNECOL,BOSTON,MA 02118
[5] MALLORY INST PATHOL,BOSTON,MA
来源：
CANCER GENETICS AND CYTOGENETICS | 1992年 / 64卷 / 01期
关键词：
D O I：
10.1016/0165-4608(92)90325-3
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We report three cases of meningioma. Case 1 had a dicentric chromosome number 22 resulting in partial monosomy for a portion of the q-arm, i.e., 46,XX,idic[22][pter --> q11.2 = q11.2 --> pter] and 46,XX,psu dic[22][pter --> q11.2 = q11.2 --> pter], which was the sole clonal abnormality. The origin of the dicentric chromosome from 22 was confirmed by in situ hybridization studies, using biotin-labeled alpha centromeric DNA probes for the acrocentric chromosomes. Case 2 had two distinct clonal abnormalities: deletion of 22q and monosomy of 22. Case 3 also had a deleted 22q.
引用
收藏
页码：65 / 68
页数：4
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