CYTOPATHOGENICITY OF ENTAMOEBA-HISTOLYTICA TO HUMAN INTESTINAL EPITHELIAL-CELLS - INHIBITION BY MONOCLONAL-ANTIBODIES AND SERA FROM AMEBIC PATIENTS

被引：2

作者：

SHANDIL, RK ^{[1
]}

VINAYAK, VK ^{[1
]}

机构：

[1] POSTGRAD INST MED EDUC & RES,DEPT EXPTL MED,DIV EXPTL PARASITOL & PARASIT IMMUNOL,CHANDIGARH 160012,INDIA

来源：

JAPANESE JOURNAL OF MEDICAL SCIENCE & BIOLOGY | 1991年 / 44卷 / 04期

关键词：

D O I：

10.7883/yoken1952.44.159

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Interactions of pathogenic Entamoeba histolytica (HM 1) with human intestinal epithelial cells (Henle - 407) were investigated. The E. histolytica trophozoites adhered and cytolysed 87% of cultured epithelial cell monolayers. A significant (P < 0.001) inhibition of cytopathic effect of amoebic trophozoites pretreated with monoclonal antibodies to a 29 kDa surface associated protein suggested utilization of the 29 kDa surface protein in recognition and cytolysis of epithelial target cells. The polyclonal sera from treated patients of amoebic liver abscess and anti-amoebic hyperimmune serum inhibited cytopathogenicity to a greater degree (P < 0.001) than did the monoclonal antibodies. The data thus suggest involvement of several amoebic molecules in exercising cytopathogenicity to epithelial cells.

引用

页码：159 / 169

页数：11

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