STRUCTURAL HOMOLOGIES AMONG THROMBOXANE (TXA2) RECEPTOR ANTAGONISTS - MINIMAL PHARMACOPHORIC REQUIREMENTS FOR HIGH-AFFINITY INTERACTION WITH TXA2 RECEPTORS

被引：4
|
作者：
LADOUCEUR, G [1 ]
MAIS, DE [1 ]
JAKUBOWSKI, JA [1 ]
UTTERBACK, BG [1 ]
ROBERTSON, DW [1 ]
机构：
[1] ELI LILLY & CO, LILLY RES LAB, DEPT CARDIOVASC PHARMACOL, INDIANAPOLIS, IN 46285 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 03期
关键词：
(+/-)-(5Z)-7-<3-ENDO-<(PHENYLSULFONYL)AMINO>BICYCLO<2.2.1>HEPT-2-EXO-YL>HEPTENO; S-145;
D O I：
10.1016/S0960-894X(01)80794-0
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Several sulfonamide derivatives related to S-145 were synthesized and tested as thromboxane receptor antagonists. The results reveal the importance of the orientation between the sulfonamide moiety and the carboxyclic acid group of the alpha-side chain in order to obtain high affinity interaction with TXA2 receptors.
引用
收藏
页码：173 / 178
页数：6
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