STRUCTURAL HOMOLOGIES AMONG THROMBOXANE (TXA2) RECEPTOR ANTAGONISTS - MINIMAL PHARMACOPHORIC REQUIREMENTS FOR HIGH-AFFINITY INTERACTION WITH TXA2 RECEPTORS

被引：4

作者：

LADOUCEUR, G ^{[1
]}

MAIS, DE ^{[1
]}

JAKUBOWSKI, JA ^{[1
]}

UTTERBACK, BG ^{[1
]}

ROBERTSON, DW ^{[1
]}

机构：

[1] ELI LILLY & CO, LILLY RES LAB, DEPT CARDIOVASC PHARMACOL, INDIANAPOLIS, IN 46285 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 03期

关键词：

(+/-)-(5Z)-7-<3-ENDO-<(PHENYLSULFONYL)AMINO>BICYCLO<2.2.1>HEPT-2-EXO-YL>HEPTENO; S-145;

D O I：

10.1016/S0960-894X(01)80794-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several sulfonamide derivatives related to S-145 were synthesized and tested as thromboxane receptor antagonists. The results reveal the importance of the orientation between the sulfonamide moiety and the carboxyclic acid group of the alpha-side chain in order to obtain high affinity interaction with TXA2 receptors.

引用

页码：173 / 178

页数：6

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