SEVERE NEUROLOGIC DEFICIT AFTER NITROUS-OXIDE ANESTHESIA

被引：30
|
作者：
HADZIC, A
GLAB, K
SANBORN, KV
THYS, DM
机构：
[1] Department of Anesthesiology, St. Luke's-Roosevelt Hospital Center, New York, NY 10025
来源：
ANESTHESIOLOGY | 1995年 / 83卷 / 04期
关键词：
ANESTHESIA; ADVERSE EFFECTS; ANESTHETICS; GASES; NITROUS OXIDE; ANEMIA; PERNICIOUS ANEMIA; COMPLICATIONS; NEUROLOGIC; PARALYSIS; SPINAL CORD; PARAPLEGIA; VITAMINS; B-12;
D O I：
10.1097/00000542-199510000-00028
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
THE interaction of nitrous oxide and vitamin B-12 is well known from experimental studies in animals and anecdotal clinical reports.(1-4) Nitrous oxide oxidizes cobalamin in vitamin B-12 and disrupts several pathways involved in one-carbon chemistry. The result is an irreversible inactivation of the enzyme methionine synthase, which requires vitamin B-12 in the +1 oxidation state to act as its coenzyme. The clinical syndrome associated with oxidation of vitamin B-12 develops after prolonged exposure to nitrous oxide and consists of megaloblastic erythropoiesis and subacute combined degeneration of the spinal cord.(2-4) We present the case of a patient who developed a severe neurologic deficit 6 weeks after anesthesia with nitrous oxide.
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收藏
页码：863 / 866
页数：4
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