THE SUSCEPTIBILITY OF THE INDONESIAN I/CDC STRAIN OF PLASMODIUM-VIVAX TO CHLOROQUINE

被引：16
|
作者：
COLLINS, WE
SCHWARTZ, IK
SKINNER, JC
MORRIS, C
FILIPSKI, VK
机构：
[1] Division of Parasitic Diseases, Natl. Center for Infectious Diseases, U.S. Dept. of Health/Human Services, Atlanta
来源：
JOURNAL OF PARASITOLOGY | 1992年 / 78卷 / 02期
关键词：
D O I：
10.2307/3283486
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
A strain of Plasmodium vivax from Indonesia was adapted to splenectomized Aotus and Saimiri monkeys and tested for its susceptibility to chloroquine. Animals were infected by intravenous inoculation of heparinized parasitized blood and subsequently treated with 8 or 15 mg (base) of chloroquine by oral intubation. Recrudescence of infection occurred in 4 of 4 Aotus and 5 of 6 Saimiri monkeys treated with 15 mg base of chloroquine, indicating a level of resistance between that of the standard Chesson strain of P. vivax and the recently reported resistant strains from Papua New Guinea.
引用
收藏
页码：344 / 349
页数：6
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