COMBINATORIAL BIOSYNTHESIS - AN APPROACH IN THE NEAR FUTURE

被引：40
|
作者：
ROHR, J
机构：
[1] Institut für Organische Chemie, Universität Göttingen, D-37077
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1995年 / 34卷 / 08期
关键词：
BIOSYNTHESES; GENE TECHNOLOGY; POLYKETIDES;
D O I：
10.1002/anie.199508811
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A gene library has been conceived for the construction of multienzyme complexes from natural and altered building blocks. The first encouraging results have been achieved with polyketide synthases (PKSs): enzyme hybrids were formed by “mixing” genes coding for PKSs, which provide novel polyketides such as 1. The ring frameworks, configurations, and/or functional groups of these novel compounds depend on the manipulated genes. (Figure Presented.) Copyright © 1995 by VCH Verlagsgesellschaft mbH, Germany
引用
收藏
页码：881 / 885
页数：5
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