user

COMBINATORIAL BIOSYNTHESIS - AN APPROACH IN THE NEAR FUTURE

被引：40
|
作者：
ROHR, J
机构：
[1] Institut für Organische Chemie, Universität Göttingen, D-37077
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1995年 / 34卷 / 08期
关键词：
BIOSYNTHESES; GENE TECHNOLOGY; POLYKETIDES;
D O I：
10.1002/anie.199508811
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A gene library has been conceived for the construction of multienzyme complexes from natural and altered building blocks. The first encouraging results have been achieved with polyketide synthases (PKSs): enzyme hybrids were formed by “mixing” genes coding for PKSs, which provide novel polyketides such as 1. The ring frameworks, configurations, and/or functional groups of these novel compounds depend on the manipulated genes. (Figure Presented.) Copyright © 1995 by VCH Verlagsgesellschaft mbH, Germany
引用
收藏
页码：881 / 885
页数：5
相关论文
共 50 条
  • [1] The multiplasmid approach: A new perspective for combinatorial biosynthesis
    Hertweck, C
    [J]. CHEMBIOCHEM, 2000, 1 (02) : 103 - 106
  • [2] Combinatorial catalysis: A help for the chemical industry of the near future
    Flego, C
    [J]. CHIMICA OGGI-CHEMISTRY TODAY, 2003, 21 (09) : 69 - +
  • [3] Combinatorial biosynthesis of carotenoids in a heterologous host: A powerful approach for the biosynthesis of novel structures
    Sandmann, G
    [J]. CHEMBIOCHEM, 2002, 3 (07) : 629 - 635
  • [4] Combinatorial biosynthesis
    Wallace, RW
    [J]. DRUG DISCOVERY TODAY, 1997, 2 (12) : 505 - 506
  • [5] Biosynthesis and Combinatorial Biosynthesis of Erythromycin
    Wu, Jiequn
    Liu, Wen
    Zhang, Siliang
    [J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2012, 32 (07) : 1232 - 1240
  • [6] Combinatorial biosynthesis
    Sundermann, Uschi
    Kushnir, Susanna
    Schulz, Frank
    [J]. NACHRICHTEN AUS DER CHEMIE, 2011, 59 (03) : 313 - 318
  • [7] Combinatorial biosynthesis in plants: A (p)review on its potential and future exploitation
    Pollier, Jacob
    Moses, Tessa
    Goossens, Alain
    [J]. NATURAL PRODUCT REPORTS, 2011, 28 (12) : 1897 - 1916
  • [8] The enzymology of combinatorial biosynthesis
    Reeves, CD
    [J]. CRITICAL REVIEWS IN BIOTECHNOLOGY, 2003, 23 (02) : 95 - 147
  • [9] Near-medians that avoid the corners; a combinatorial probability approach
    Larlee, Caroline Anne
    Zheng, Chunfang
    Sankoff, David
    [J]. BMC GENOMICS, 2014, 15
  • [10] Tracking elementary particles near their primary vertex: A combinatorial approach
    Pusztaszeri, JF
    Rensing, PE
    Liebling, TM
    [J]. JOURNAL OF GLOBAL OPTIMIZATION, 1996, 9 (01) : 41 - 64
12345