INDUCIBLE PRODUCTION OF MACROPHAGE COLONY-STIMULATING FACTOR (CSF-1) BY MALIGNANT AND NORMAL HUMAN T-CELLS

被引：0
|
作者：
PRALORAN, V [1 ]
GASCAN, H [1 ]
PAPIN, S [1 ]
CHEVALIER, S [1 ]
TROSSAERT, M [1 ]
BOURSIER, MC [1 ]
机构：
[1] CTR HOSP REG & UNIV,INSERM,U211,F-44035 NANTES,FRANCE
来源：
LEUKEMIA | 1990年 / 4卷 / 06期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The CEM-ON malignant T cell line and long-term cultured normal T cells can be induced to release CSF-1 in their culture supernatants. Chemical inducers (PMA + A23187) and, more interestingly, cytokines (tumor necrosis factor-alpha (TNF-alpha) and interleukin-1-alpha (IL-1-alpha)), as well as physiological (antigen + IL-2) or specific (anti-CD3 + IL-2 or PMA) stimuli, lead to rapid transient colony-stimulating factor-1 (CSF-1) gene expression and production of biologically active CSF-1. These data suggest that CSF-1 may play a role in the early phases of immune response.
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页码：411 / 414
页数：4
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