MODEL SELECTION FOR THE ADSORPTION OF PHENOBARBITAL BY ACTIVATED-CHARCOAL

被引：12

作者：

BURKE, GM ^{[1
]}

WURSTER, DE ^{[1
]}

BURAPHACHEEP, V ^{[1
]}

BERG, MJ ^{[1
]}

VENGPEDERSEN, P ^{[1
]}

SCHOTTELIUS, DD ^{[1
]}

机构：

[1] UNIV IOWA,COLL PHARM,IOWA CITY,IA 52242

来源：

PHARMACEUTICAL RESEARCH | 1991年 / 8卷 / 02期

关键词：

PHENOBARBITAL; ADSORPTION; ACTIVATED CHARCOAL; LANGMUIR; FREUNDLICH; HEAT OF DISPLACEMENT;

D O I：

10.1023/A:1015800322286

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Activated charcoal is known to adsorb a wide variety of substances from solution, and several equations have been used to fit the resulting adsorption data. The determination of the correct model to fit phenobarbital adsorption onto activated charcoal was made using a calorimetric method. The differential heats of displacement of water by phenobarbital for four activated charcoals were determined and found to be linearly related to the amount of phenobarbital adsorbed. The activated charcoals studied had statistically similar heats of displacement. The linear relationship between heat evolved and the amount of phenobarbital adsorbed is consistent with the assumptions implicit in the Langmuir model.

引用

页码：228 / 231

页数：4

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