MODEL SELECTION FOR THE ADSORPTION OF PHENOBARBITAL BY ACTIVATED-CHARCOAL

被引：12
|
作者：
BURKE, GM [1 ]
WURSTER, DE [1 ]
BURAPHACHEEP, V [1 ]
BERG, MJ [1 ]
VENGPEDERSEN, P [1 ]
SCHOTTELIUS, DD [1 ]
机构：
[1] UNIV IOWA,COLL PHARM,IOWA CITY,IA 52242
来源：
PHARMACEUTICAL RESEARCH | 1991年 / 8卷 / 02期
关键词：
PHENOBARBITAL; ADSORPTION; ACTIVATED CHARCOAL; LANGMUIR; FREUNDLICH; HEAT OF DISPLACEMENT;
D O I：
10.1023/A:1015800322286
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Activated charcoal is known to adsorb a wide variety of substances from solution, and several equations have been used to fit the resulting adsorption data. The determination of the correct model to fit phenobarbital adsorption onto activated charcoal was made using a calorimetric method. The differential heats of displacement of water by phenobarbital for four activated charcoals were determined and found to be linearly related to the amount of phenobarbital adsorbed. The activated charcoals studied had statistically similar heats of displacement. The linear relationship between heat evolved and the amount of phenobarbital adsorbed is consistent with the assumptions implicit in the Langmuir model.
引用
收藏
页码：228 / 231
页数：4
相关论文
共 50 条
  • [1] INVITRO ADSORPTION OF PHENOBARBITAL ONTO ACTIVATED-CHARCOAL
    JAVAID, KA
    ELMABROUK, BH
    [J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1983, 72 (01) : 82 - 85
  • [2] ACTIVATED-CHARCOAL IN PHENOBARBITAL OVERDOSE
    GOLDBERG, MJ
    BERLINGER, WG
    PARK, GD
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1985, 253 (08): : 1120 - 1121
  • [3] ACTIVATED-CHARCOAL IN PHENOBARBITAL OVERDOSE - REPLY
    POND, SM
    OSTERLOH, JD
    OLSON, KR
    TONG, TG
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1985, 253 (08): : 1121 - 1121
  • [4] TREATMENT OF PHENOBARBITAL OVERDOSE WITH ACTIVATED-CHARCOAL
    GOLDBERG, MJ
    BERLINGER, WG
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1982, 247 (17): : 2400 - 2401
  • [5] ADSORPTION OF TETRANITRONITROSYLRUTHENATE ON ACTIVATED-CHARCOAL
    AKATSU, E
    YONEZAWA, C
    MOTOJIMA, K
    [J]. ANNALS OF NUCLEAR ENERGY, 1979, 6 (7-8) : 399 - 404
  • [6] ADSORPTION OF ETHER BY ACTIVATED-CHARCOAL
    CUNDY, JM
    [J]. ANESTHESIOLOGY, 1978, 48 (01) : 77 - 77
  • [7] ACTIVATED-CHARCOAL ADSORPTION OF DIPHENHYDRAMINE
    GUAY, DRP
    MEATHERALL, RC
    MACAULAY, PA
    YEUNG, C
    [J]. INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, 1984, 22 (08) : 395 - 400
  • [8] ADSORPTION OF ARSENIC ON ACTIVATED-CHARCOAL
    EGUEZ, HE
    CHO, EH
    [J]. JOURNAL OF METALS, 1987, 39 (07): : 38 - 41
  • [9] HEPARIN ADSORPTION ON ACTIVATED-CHARCOAL
    COONEY, DO
    [J]. CLINICAL TOXICOLOGY, 1977, 11 (05): : 569 - 572
  • [10] THE EFFECT OF ORAL ACTIVATED-CHARCOAL ON THE ELIMINATION OF PHENOBARBITAL
    GOLDBERG, MJ
    BERLINGER, WG
    BERG, MJ
    SPECTOR, R
    JOHNSON, GF
    [J]. CLINICAL RESEARCH, 1982, 30 (02): : A487 - A487
12345