THE CALCIUM ATPASE OF SARCOPLASMIC-RETICULUM IS INHIBITED BY ONE CA-2+ ION

被引：12
|
作者：
KHANANSHVILI, D [1 ]
MYUNG, J [1 ]
KOLOUCH, R [1 ]
JENCKS, WP [1 ]
机构：
[1] BRANDEIS UNIV,GRAD DEPT BIOCHEM,WALTHAM,MA 02254
来源：
FEBS LETTERS | 1990年 / 260卷 / 01期
关键词：
ATPase; calcium; Calcium; Inhibition;
D O I：
10.1016/0014-5793(90)80071-P
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Inhibition by calcium of the steady-state turnover of the calcium ATPase from sarcoplasmic reticulum of rabbit muscle follows a Hill slope of 0.8 ± 0.2 (pH 7.0, 0.1 M KCl, varying [Mg2+] and 2 μM A23187 ionophore). It is concluded that dissociation of the two Ca2+ ions from E-P·Ca2 is sequential and that the inhibition arises from the binding of one Ca2+ to A-P·Ca1. © 1990.
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页码：83 / 84
页数：2
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