GENETIC SUSCEPTIBILITY BIOMARKERS IN STUDIES OF OCCUPATIONAL AND ENVIRONMENTAL CANCER - METHODOLOGIC ISSUES

被引：3
|
作者：
ROTHMAN, N
机构：
[1] Occupational Studies Section, Environmental Epidemiology Branch, NIH/NCI EPN 418, Bethesda
来源：
TOXICOLOGY LETTERS | 1995年 / 77卷 / 1-3期
关键词：
CANCER EPIDEMIOLOGY; BIOMARKERS; STUDY DESIGN; ENZYME POLYMORPHISM;
D O I：
10.1016/0378-4274(95)03298-3
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
When using biomarkers to assess genetic susceptibility for cancer risk, the following issues should be recognized: (i) exposure assessment should receive as much attention as marker measurement; (ii) it is critical to study cases with a wide range of exposure patterns; (iii) each approach to evaluating susceptibility has its own potential biases; (iv) it is important to demonstrate the biologic plausibility of gene-exposure interactions detected in epidemiologic studies.
引用
收藏
页码：221 / 225
页数：5
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