DISTRIBUTION OF CEREBROSPINAL-FLUID OLIGOCLONAL IGM BANDS IN NEUROLOGICAL DISEASES - A COMPARISON BETWEEN AGAROSE ELECTROPHORESIS AND ISOELECTRIC-FOCUSING

被引：9
|
作者：
SHARIEF, MK [1 ]
THOMPSON, EJ [1 ]
机构：
[1] INST NEUROL, DEPT CLIN NEUROCHEM, LONDON WC1N 3BG, ENGLAND
来源：
JOURNAL OF THE NEUROLOGICAL SCIENCES | 1992年 / 109卷 / 01期
关键词：
IGM; OLIGOCLONAL BANDS; CEREBROSPINAL FLUID; AGAROSE GEL ELECTROPHORESIS; ISOELECTRIC FOCUSING; MULTIPLE SCLEROSIS;
D O I：
10.1016/0022-510X(92)90098-6
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Isoelectric focusing (IEF) and agarose gel electrophoresis were used to detect oligoclonal IgM bands in cerebrospinal fluid and serum samples from 850 patients with diverse neurological diseases. Oligoclonal IgM bands in cerebrospinal fluid were mainly detected in patients with infectious and inflammatory disorders of the nervous system. Both IEF and agarose electrophoresis revealed similar frequencies of oligoclonal IgM bands. Bands detected by IEF were mainly seen in the anodal range. Despite higher resolving capacity, IEF was less specific than agarose gel electrophoresis. It is concluded that oligoclonal IgM bands have important diagnostic significance and that agarose gel electrophoresis is more suitable for their detection in routine clinical work and use in differential diagnosis.
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页码：83 / 87
页数：5
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