DISTRIBUTION OF CEREBROSPINAL-FLUID OLIGOCLONAL IGM BANDS IN NEUROLOGICAL DISEASES - A COMPARISON BETWEEN AGAROSE ELECTROPHORESIS AND ISOELECTRIC-FOCUSING

被引：9

作者：

SHARIEF, MK ^{[1
]}

THOMPSON, EJ ^{[1
]}

机构：

[1] INST NEUROL, DEPT CLIN NEUROCHEM, LONDON WC1N 3BG, ENGLAND

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1992年 / 109卷 / 01期

关键词：

IGM; OLIGOCLONAL BANDS; CEREBROSPINAL FLUID; AGAROSE GEL ELECTROPHORESIS; ISOELECTRIC FOCUSING; MULTIPLE SCLEROSIS;

D O I：

10.1016/0022-510X(92)90098-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Isoelectric focusing (IEF) and agarose gel electrophoresis were used to detect oligoclonal IgM bands in cerebrospinal fluid and serum samples from 850 patients with diverse neurological diseases. Oligoclonal IgM bands in cerebrospinal fluid were mainly detected in patients with infectious and inflammatory disorders of the nervous system. Both IEF and agarose electrophoresis revealed similar frequencies of oligoclonal IgM bands. Bands detected by IEF were mainly seen in the anodal range. Despite higher resolving capacity, IEF was less specific than agarose gel electrophoresis. It is concluded that oligoclonal IgM bands have important diagnostic significance and that agarose gel electrophoresis is more suitable for their detection in routine clinical work and use in differential diagnosis.

引用

页码：83 / 87

页数：5

共 50 条

[1] OLIGOCLONAL BANDS IN CEREBROSPINAL-FLUID DETECTED BY PHASTSYSTEM ISOELECTRIC-FOCUSING
WYBO, I
VANBLERK, M
MALFAIT, R
GOUBERT, P
GORUS, F
[J]. CLINICAL CHEMISTRY, 1990, 36 (01) : 123 - 125
[2] CFS OLIGOCLONAL BANDS IN MS AND OTHER NEUROLOGICAL DISEASES DETECTED BY AGAROSE ISOELECTRIC-FOCUSING AND ELECTROPHORESIS
CERRATO, D
SALMAGGI, A
ARIANO, C
LAMANTIA, L
NESPOLO, A
[J]. ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES, 1984, 5 (03): : 303 - 310
[3] ISOELECTRIC-FOCUSING AND IMMUNOFIXATION OF CEREBROSPINAL-FLUID OLIGOCLONAL IGG IN NEUROLOGICAL DISORDERS
RUBIN, DB
MEHTA, PD
NATHANSON, M
[J]. DIAGNOSTIC IMMUNOLOGY, 1985, 3 (03): : 160 - 162
[4] AGAROSE ISOELECTRIC-FOCUSING, ANTISERUM IMMUNOFIXATION AND SILVER STAINING FOR DETECTION OF OLIGOCLONAL BANDS IN UNCONCENTRATED CEREBROSPINAL-FLUID
RADOSAVLJEVIC, B
[J]. ACTA NEUROLOGICA SCANDINAVICA, 1986, 73 (02): : 208 - 212
[5] DETECTION OF OLIGOCLONAL IGG BANDS IN CEREBROSPINAL-FLUID BY ISOELECTRIC-FOCUSING ON THIN-LAYER AGAROSE GELS
LANE, JR
BOWLES, KJ
NORMANSELL, DE
[J]. ANNALS OF CLINICAL AND LABORATORY SCIENCE, 1983, 13 (04): : 340 - 340
[6] COMPARISON BETWEEN AGAROSE-GEL ELECTROPHORESIS AND ISOELECTRIC-FOCUSING OF CSF FOR DEMONSTRATION OF OLIGOCLONAL IMMUNOGLOBULIN BANDS IN NEUROLOGICAL DISORDERS
LAURENZI, MA
LINK, H
[J]. ACTA NEUROLOGICA SCANDINAVICA, 1978, 58 (03): : 148 - 156
[7] ISOELECTRIC-FOCUSING PATTERNS OF CEREBROSPINAL-FLUID IN DEGENERATIVE NEUROLOGICAL DISEASES
STIBLER, H
KJELLIN, KG
[J]. ACTA NEUROLOGICA SCANDINAVICA, 1976, 54 (01): : 119 - 120
[8] AGAROSE ISOELECTRIC-FOCUSING OF CEREBROSPINAL-FLUID AND SERUM EVALUATED ON 998 NEUROLOGICAL PATIENTS
KOSTULAS, VK
LINK, H
[J]. ACTA NEUROLOGICA SCANDINAVICA, 1982, 65 : 266 - 267
[9] UTILITY OF ISOELECTRIC-FOCUSING OF CEREBROSPINAL-FLUID AND SERUM ON AGAROSE EVALUATED FOR NEUROLOGICAL PATIENTS
LINK, H
KOSTULAS, V
[J]. CLINICAL CHEMISTRY, 1983, 29 (05) : 810 - 815
[10] CEREBROSPINAL-FLUID OLIGOCLONAL BANDS DETECTED BY PHAST SYSTEM-R ISOELECTRIC-FOCUSING
GORUS, F
GOUBERT, P
MALFAIT, R
WYBO, I
VANBLERK, M
[J]. ANNALES DE BIOLOGIE CLINIQUE, 1988, 46 (07) : 585 - 585

← 1 2 3 4 5 →