Breast cancer contributes for 5-8% of all cancer in India, and there is a rising trend in its incidence as the most common type of cancer in urban Indian women and the second most common type of cancer in rural women. The probability of developing breast cancer during lifetime in Indian women is 1 in 22 as compared to 1 in 8 women in the United States and other developed countries. There are considerable variations in risk factors, presenting stage and prognostic factors such as receptor status. AIM To evaluate the clinical profile of patients presenting with breast cancer to a tertiary care hospital, MIMS, Mandya. MATERIALS AND METHODS It was an observational, cross-sectional study done in the Department of Surgery/Onco Surgery, MIMS, Mandya, a tertiary care centre from Oct. 2015 to March 2016. Patients diagnosed as carcinoma breast were registered; detailed history, clinical examination and necessary investigations performed. RESULTS AND CONCLUSIONS The incidence was high (80%) among women age ranging from 30 to 60. The majority of women presented with lump (90%) and others with nipple retraction (14%), ulceration (20%), discharge (10%), and symptoms of metastasis (12%). Upper outer quadrant was the common site of tumour in more than 50% of patients, IDC was the common histology, most of patients presented in stage 2/3.