EFFECTS OF PROPHYLACTIC CHEMOTHERAPY FOR POSTMOLAR TROPHOBLASTIC DISEASE IN PATIENTS WITH COMPLETE HYDATIDIFORM MOLE

被引：5

作者：

AYHAN, A

ERGENELI, MH

YUCE, K

YAPAR, EG

KISNISCI, AH

机构：

[1] Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Faculty of Medicine, Ankara

来源：

INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS | 1990年 / 32卷 / 01期

关键词：

Hydatidiform mole; Methotrexate; Postmolar gestational trophoblastic disease; Prophylactic chemotherapy; Toxicity;

D O I：

10.1016/0020-7292(90)90980-Y

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

An analysis of 233 patients with complete hydatidiform mole admitted to Hacettepe University Hospital between 1964 and 1988 has been carried out. Methotrexate was administered prophylactically to 19 of 120 low-risk and to 52 of 113 high-risk patients. The difference in the incidence of postmolar gestational trophoblastic disease between prophylactically untreated and treated groups of either low-risk (13.9% versus 5.3%, P > 0.01) or high-risk (26.2% versus 25.0%, P > 0.01) patients was found to be statistically insignificant. Drug toxicity and mortality rates were 16.9% and 2.8%, respectively. It is concluded that prophylactic chemotherapy is not highly effective in the prophylaxis of postmolar gestational trophoblastic disease. Strict follow-up through sensitive betahuman chorionic gonadotropin assays should be the standard management of postmolar patients. © 1990.

引用

页码：39 / 41

页数：3

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