DETERMINATION OF MEPROBAMATE IN HUMAN PLASMA, URINE, AND HAIR BY GAS-CHROMATOGRAPHY AND ELECTRON-IMPACT MASS-SPECTROMETRY

被引：19
|
作者：
KINTZ, P
MANGIN, P
机构：
[1] Institut de Médecine Légale, Strasbourg Cedex, 67085
来源：
JOURNAL OF ANALYTICAL TOXICOLOGY | 1993年 / 17卷 / 07期
关键词：
D O I：
10.1093/jat/17.7.408
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A sensitive and specific quantitative assay for the determination of meprobamate in human fluids and hair is described. Meprobamate and an internal standard, vinylbarbital, are isolated by acid extraction and methylated by derivatization. The final extract is separated on a 12-m capillary column HP-1 and drugs are detected by selected ion monitoring at m/z 162 and m/z 182 for meprobemate and the internal standard, respectively. Applications in forensic science, particularly for hair analysis, are presented. © 1993 Oxford University Press.
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页码：408 / 410
页数：3
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