SEQUENCE ALIGNMENT OF THE G-PROTEIN COUPLED RECEPTOR SUPERFAMILY

被引：747
|
作者：
PROBST, WC
SNYDER, LA
SCHUSTER, DI
BROSIUS, J
SEALFON, SC
机构：
[1] CUNY MT SINAI SCH MED, FISHBERG RES CTR NEUROBIOL, BOX 1065, 1 GUSTAVE L LEVY PL, NEW YORK, NY 10029 USA
[2] CUNY MT SINAI SCH MED, DEPT NEUROL, NEW YORK, NY 10029 USA
[3] NYU, DEPT CHEM, NEW YORK, NY 10003 USA
[4] CUNY GRAD SCH & UNIV CTR, PHD PROGRAM BIOL, NEW YORK, NY 10036 USA
来源：
DNA AND CELL BIOLOGY | 1992年 / 11卷 / 01期
关键词：
D O I：
10.1089/dna.1992.11.1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The multitude of G-protein coupled receptor (GPR) superfamily cDNAs recently isolated has exceeded the number of receptor subtypes anticipated by pharmacological studies. Analysis of the sequence similarities and unique features of the members of this family is valuable for designing strategies to isolate related cDNAs, for developing hypotheses concerning substrate-ligand and receptor-effector interactions, and for undertanding the evolution of these genes. We have compiled and aligned the 74 unique amino acid sequences published to date and review the present understanding of the structural motifs contributing to ligand binding and G-protein coupling.
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页码：1 / 20
页数：20
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