Toll-like Receptors in Host Defense and Immune Disorders

被引：0

作者：

Lee, Joo Y. ^{[1
]}

机构：

[1] Gwangju Inst Sci & Technol, Dept Life Sci, Gwangju 500712, South Korea

来源：

TOXICOLOGICAL RESEARCH | 2007年 / 23卷 / 02期

关键词：

Toll-like receptor; Immune dysfunction; Inflammation; Infection; Innate and Adaptive immunity;

D O I：

10.5487/TR.2007.23.2.097

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Toll-like receptors (TLRs) play a crucial role in initiating and regulating innate and adaptive immune responses by detecting invading microbial pathogens. TLRs can also respond to non-microbial molecules derived from damaged tissue. Accumulating evidence suggests that deregulation of TLRs results in the dysfunction of immune system and ultimately increases the risk of many immune and inflammatory diseases including infectious diseases, allergy, and autoimmune diseases. Therefore, understanding how the immune system is controlled by TLRs will provide new insight to find the way to prevent or treat infectious diseases and immune disorders.

引用

页码：97 / 105

页数：9

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